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EtOH, intro to neurodegen, PD

QuestionAnswer
Acetaldehyde syndrome Inhibitors of Acetaldehyde DeHase * Metronidazole * Cephalosporins with NMTT (cefaperazone, cefamandol) * tolbutamide * chlorpropamide
Disulfuram (ANTABUSE) * inhibits acetaldehyde DeHase * EtOh Adversion Technique * EtOH received during this treatment leads to acetaldehyde syndrome * Subject can't intake EtOH 3 - 14 days after disulfuram admin
Drugs to reduce craving & autonomic manifestations of dependence 1. clonide 2. naltrexone 3. acamprosate (NMDA Antagonist) [BDZ (affect Cl ch) + NMDA Antagonist)] --> Good to titrate pt from sed hypnotic (EtOH)
Fomepizole ANTIZOLE * inhibits the conversion of Alcohols to Aldehydes (inc excretion of parent cmpd)
Donepezil Aricept * Cholinesterase Inhibitors (inc ACH activity; Alzheimer's)
Rivastigmine Exelon * Cholinesterase Inhibitors (inc ACH activity; Alzheimer's)
Galantamine Razadyne * Cholinesterase Inhibitors (inc ACH activity; Alzheimer's)
Tacrine Cognex * Cholinesterase Inhibitors (inc ACH activity; Alzheimer's)
Nemantine NAMEDNA * NMDA R Antagonist
Riluzole RILUTEK * inhibits Glutaminergic neuronal activity & release; inh voltage-gated Na+ Chs * Amylotrophic Lateral Sclerosis. * reduces spasticity, but not dz; * Hepatotoxic
Glucocorticoids MS tx anti-inflammatory
Interferon beta1a AVONEX * reduce T lymphocyte activity against myelin
Glatiramer acetate COPAXONE * 4 aa peptide that induces T cells to secrete cytokines to reduce lesion pdtn
LDOPA/carbidopa SINEMET * LDOPA gets into CNS via aa TRA * carbidopa inhibits peripheral decarboxylation
SINEMET Warnings/Precautions Abrupt withdrawal causes Neuroleptic Malignant Syndrome: inc body temp, muscle rigidity, and tachycardia/sweating; malignant melanoma, or lower seizure threshold.
SINEMET DDIs (4): 1. Antipsychotic agents 2. Anticholinergic agents 3. Nonselective MAOIs 4. Methyldopa
Amantadine SYMMETREL * Modifies DA TRA * inc DA release & inhs reuptake * AE: levido reticularis: blotches on skin due to excessive skin vasodilation.
SYMMETREL DDIs (2) 1. Anticholinergic drugs 2. CNS Stimulants
Entacapone COMTAN * Inhibits COMT * Used w SINEMET (STALEVO?) * Elim via biliary excretion
COMTAN DDIs (2): 1. Nonselective MAOIs 2. Drugs metabolized by COMT: bitolerol, dobutamine, DA, E, isoproterenol, methyldopa, NE
Tolcapone TASMAR * older COMT Inhibitor * RENAL EXCRETION! *FUlminant Liver Failure * Interferes with Warfarin/INR
Selegiline Hydrochloride ELDEPRYL * MAOB Inh * inc AE of LDOPA
Rasagiline AZILECT * MAOb Inhib
ELDEPRYL DDIs (4): 1. Tyramine rxns 2. Meperidine 3. SSRIs 4. Catecholamines
Bromocriptine PARLODEL * ERgot alkaloid * DA agonist
Pergolide PERMAX * ergot alkaloid * DA agonist
Pramipexole MIRAPEX * nonergot alkaloids * suddenly fall asleep * elimin (renal exc) is dec with cimetidine, ranitidne, verapamil, quinidine
Ropinirole REQUIP * oonergot alkaloid DA agonist * metab by CYP1A2, inhb by CIPRO * effect reduced by antipsychotics
Benztropiine COGENTIN * PD Anticholinergic Drugs
Trihexyphenidyl ARTANE * PD Anticholinergic Drugs
Diphenhydramine BENADRYL * PD Anticholinergic Drugs
Created by: 24504011
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