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RAAS

PCOL - Exam 2

Name MOASOASide Effects
Aliskiren Selective Renin Inhibitor Reversible antagonist Blood Stream (renin - 1st step in RASS pathway) Lower TPR Lower aldosterone Decrease sodium and water reabsorption Angioedema, hypotension, cough, headache, diarrhea, skin rash
Captopril Enalapril (Vasotec) Lisinopril (Prinivil) Benazepril (Lotensin) Quinapril (Accupril) Ramipril (Altace) ACE inhibitor Angiotensisn converting enzyme inhibitor Reversible antagonist Blood stream Lower TPR Lower Aldosterone Decrease sodium and water reabsorption dry cough, hyperkalemia, angioedema, first dose hypotension, fetopathic potential
Losartan (Coozar) Valsartan (Diovan) Olmesartan (benicar) Telmisarn (Micardis) Irbesartan (avapro) MEdoxomil ARB Angiotensin II receptor blockers Reversible Antagonist Blood Stream Lower TPR Lower Aldosterone Decrease sodium and water reabsorption
Spironolactone Elperenone Potassium-sparing diuretic Mineralocorticoid (MR) Receptor antagonsit Kidney -> collecting duct of nephron Hyperkalemia, diarrhea, drowsiness Males: gynecomastia and impotence
Metoprolol Selective B1 blocker Kidney Less Renin production -> no RAAS pathway
Created by: timothyjg.2
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