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Adrenergic

PCOL - Exam 2

NameMOASOASide Effects
Phenylephrine a1 agonist Blood Vessels Eyes HTN, ocular burning, nasal discharge, rebound congestions
Cocaine NE uptake inhibitor CNS HTN, tachycardia, arrythmias, restlessness
Dextroamphetamine and amphetamine (Adderall) Methylphenidate (Concerta, Ritalin) Lisdexamphetamine (Vyvanse) Dexmethylphenidate (Focalin) Stimulate pre-synaptic release of NE and DA CNS HTN, tachycardia, arrythmias, restlessness, loss of appetite
Pheneizine Non-selective MOA-A and MOA-B irreversible antagonist CNS HTN, tachycardia, arrythmias, restlessness
Selegiline Rasagiline Selective MOA-B irreversible antagonist CNS HTN, tachycardia, arrythmias, restlessness
Prazosin Terazosin (Hytrin) Doxazosin (Cardura) Tamsulosin (Flomax) Selective a1 antagonist reversible Brain, Eye, Nose, Blood vessels, Urethra Headache, blurred vision, orthostatic hypotension, sexual dysfunction
Mirtazapine (Remeron) Non-selective a1, a2, Muscarinic, 5-HT 2a, and H1 antagonist CNS Enhances release of NE and 5-HT (Serotonin), Peripheral edema, HTN Drowsiness, weight gain, increased cholesterol, xerostomia, comstipation
Phenoxybenzamine Non-selective a1 and a2 antagonist irreversible Decreased peripheral resistance Brain Eye Nose Blood Vessels Urethra GI Orthostatic hypotension, GI stimulation, headache, miosis
Clonidine (Catapres) Brimondine (Alphagan P) Tizanidine (Zanaflex Guafacine (Intuniv) Dexmedetomidine (Precedex) a2 Agonist CNS Enhance inhibitory/suppress SNS Sedation, dry mouth, hypotension, bradycardia, sexual dysfunction, depression, constipation
Dobutamine B1 agonist Heart, Kidneys, Brain Decreased heart rate and contractibility, fatigue, dizziness, bradycardia, decreased RASS, CNS depression
Metoprolol (Lopressor or Toprol) Atenlol (Tenormin) Nebivolol (Bystolic) B1 antagonist (B1 beta-blockers) Heart, kidneys, brain Decreased heart rate and contractility, fatigue, dizziness, bradycardia, decreased RAAS, CNA depression
SABA Albuterol (Ventolin) Levalbuterol (Xopenex) LABA: Salmeterol Formoterol B2 agonist Lungs Vasculature CNS Bronchial Dilation Vasodilation Excitation
Propranolol (Inderal) Pindolol (partial agonist) Timolol (Betimol) Non-selective beta-blockers B1 and B2 antagonist Heart Kidneys Brain Lungs Vasculaure Decreased heart rate, contractility, fatigue, dizziness, decreased RASS, CNS depression
Carvedilol (Coreg) Labetalol (Trandate) B1 and B2 antagonist and A1 Agonist Heart Kidneys Brain Lungs Vasculature Decreased heart rate, contractility, fatigue, dizziness bradycardia, decreased RAAS, CNS depression
Mirabegron B3 agonist Bladder Relief for overactive bladder
Epinephrine B1, B2 agonist (blood vessels) Heart and vasculature Adrenergic receptors SNS activation
Norepinephrine (Levophed) A1 and B1 agonist Heart and Vasculature Increase TPR, heart rate, and contractility
Isoproterenol B1, B2 agonist (lungs) Heart and Lungs Hyperglycemia, palpitations, tachycardia, arrythmia
Created by: timothyjg.2
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