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Cholinergic

PCOL - Exam 2

NameMOASOASide Effects
Acetylcholine Methacholine Cabachol Bethanchol Non- Selective Muscarinic Agonist (M1-M3) CNS and periphery DUMBBELLS
Pilo carpine Cevimeline Non-selective Muscarinic Agonist (M1-M3) CNS and Periphery DUMBBELLS
Atropine Non-selective Muscarinic Antagonist (M1-M3) CNS and peroiphery Anti-DUMBBELLS
Scopolamine Non-selective Muscarinic Antagonist (M1-M3) CNS- Penetrate CNS more rapidly Anti-DUMBBELLS
Benztropine (Cogentin) Non-selective Muscarinic Antagonist (M1-M3) CNS Anti-DUMBBELLS
Tropicamide Muscarinic Antagonist Eyes Anti-DUMBBELLS
Ipratropium (Atrovent) Non-seledtive Muscarinic Antagonist (M1-M3) Lungs Anti-DUMBBELLS
Tiotropium (spriva) Selective Muscarinic Antagonist (M1 and M3) Lungs Anti-DUMBBELLS
Aclidinium Umeclindinium Muscarinic Antagonist Lungs Anti-DUMBBELLS
Oxybutynin (Ditropan) Tolterodine (Detrol) Fesoterodine(Toviaz) Solifenacin (Vesicare) Darifenacin Trospium Non-selective Muscarnic Antagonist (M1-M3) All more selective for M3 M3 in Bladder All can cause Anti-DUMBBELLS
Nitroglycerine Nitroprusside Isosorbide di/mononitrate DOnate nitric oxide Icrease sGC then increase in cGMP Endothelium of blood vessels M3 Vasodilation Lower blood pressue
Sildenafil (Viagra) Tadalafil (Cialis) Vardenafil Blocks PDE increase in cGMP Endothelium of blood vessels (M3) Vasodilation Lowers blood pressure
Created by: timothyjg.2
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