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NMJ
PCOL - Exam 2
| Name | MOA | SOA | Side Effects |
|---|---|---|---|
| Acetylcholine | Nicotinic and Muscarinic Receptor Depolarizing Agent | All over body | DUMBBELLS |
| Varenicline (Chantix) | a4/B2 Nn partial agonist | CNS (Nn) | Headache, insomnia, suicidal thoughts, flatulence |
| Succinylcholine | Depolarizing Agent Nicotinic Neuromuscular blocker | NMJ (Nm) Can affect autonomic ganglia | NMJ Paralysis, hyperalkemia, HTN and arrhythmia, muscle pain, hyperthermia |
| Phyostigmine | Cholinesterase inhibitor (Ache Antagonist) | CNS and Periphery | DUMBBELLS |
| Donepezil (Aricept) Rivastigmine (Exelon) Galantamine | Cholinesterase Inhibitors (Ache antagonist) | CNS and Periphery | DUMBBELLS |
| Pyridostigmine Neosatigmine | Cholinesterase inhibitor (Ache antagonist) | NMJ | DUMBBELLS No CNS effect |
| Edrophonium | Cholinesterase inhibitor (Ache antagonist) | NMJ | DUMBELLS No CNS effect |
| Echothiophate | Organophosphate inhibitor of acetylcholinesterase enzyme | M3 receptor in ciliary (eye) muscle | Miosis and blurred vision, lacrimation, stinging/redness of eye |
| Botulinum Toxin (botox) | Prevent Ach release | Presynaptic terminal | muscle relaxation |
| Curare and Curare like Mivacurium Vercurium Rocuronium Pancuronium Tubocurarine | Non depolarizing agent Direct competitive antag. to Ach binging pockets | NMJ | NMJ paralysis, histamine release, hypotension and tachycardia No CNS effecr |