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NMJ

PCOL - Exam 2

NameMOASOASide Effects
Acetylcholine Nicotinic and Muscarinic Receptor Depolarizing Agent All over body DUMBBELLS
Varenicline (Chantix) a4/B2 Nn partial agonist CNS (Nn) Headache, insomnia, suicidal thoughts, flatulence
Succinylcholine Depolarizing Agent Nicotinic Neuromuscular blocker NMJ (Nm) Can affect autonomic ganglia NMJ Paralysis, hyperalkemia, HTN and arrhythmia, muscle pain, hyperthermia
Phyostigmine Cholinesterase inhibitor (Ache Antagonist) CNS and Periphery DUMBBELLS
Donepezil (Aricept) Rivastigmine (Exelon) Galantamine Cholinesterase Inhibitors (Ache antagonist) CNS and Periphery DUMBBELLS
Pyridostigmine Neosatigmine Cholinesterase inhibitor (Ache antagonist) NMJ DUMBBELLS No CNS effect
Edrophonium Cholinesterase inhibitor (Ache antagonist) NMJ DUMBELLS No CNS effect
Echothiophate Organophosphate inhibitor of acetylcholinesterase enzyme M3 receptor in ciliary (eye) muscle Miosis and blurred vision, lacrimation, stinging/redness of eye
Botulinum Toxin (botox) Prevent Ach release Presynaptic terminal muscle relaxation
Curare and Curare like Mivacurium Vercurium Rocuronium Pancuronium Tubocurarine Non depolarizing agent Direct competitive antag. to Ach binging pockets NMJ NMJ paralysis, histamine release, hypotension and tachycardia No CNS effecr
Created by: timothyjg.2
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