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musculoskeletal mech

pharm drugs

QuestionAnswer
Ibuprofen, naproxen, indomethacin, ketorolac reversibly inhibit cyclooxygenase (both COX-1 and COX-2). Block prostaglandin synthesis
Ccelecoxib reversibly inhibit COX-2 isoform found in inflammatory cells and vascular endothelium and mediates inflammation and pain; spares COX-1 which helps maintain the gastric mucosa, no corrosive affects of other NSAIDS on GI lining
Acetaminophen reversibly inhibits cyclooxygenase, mostly in CNS, inactivated peripherally
Etidronate, pamidronate, alendronate, risedronate inhibit osteocalstic activity; reduce both formation and resorption of hydroxyapatite
Colchicine binds to and stabilizes tubulin to inhibit polymerization, impairing leukocyte chemotaxis and degranulation
Probenecid inibits reabsorption of uric acid in PCT
Allopurinol inhibits xanthine oxidase, v conversion of xanthine to uric acid
Etanercept recombinant form of human TNF receptor than binds TNF
Infliximab anti-TNF ab
Adalimumab directly binds TNF-alpha
Created by: 100000525771512
Popular Pharmacology sets

 

 



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