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Ch.13
Drug-to-disease Interactions
| Term | Definition |
|---|---|
| Acyclovir (Zovirax) | Affected by kidney disease |
| Allopurinol (zyloprim) | Affected by kidney disease |
| Aminoglycoside antibacterials (Amikin,gentamicin, tobramycin | Affected by kidney disease |
| Bivalirudin(Angiomax) | Affected by Kidney disease |
| Ciprofloxacin (Cipro) | Affected by kidney disease |
| Digoxin(Lanoxin) | Effected by kidney disease |
| Dofetilide (Tikosyn) | Affected by kidney disease |
| Enoxaparin (Lovenox) | Affected by kidney disease |
| Eptifibatide (Integrilin) | Affected by kidney disease |
| Flecainide (Tambocor) | Affected by kidney disease |
| Fondaparinux (Arixtra) | Affected by kidney disease |
| HCTZ | Affected by kidney disease |
| Lithium (Lithobid) | Affected by kidney disease |
| Metformin (Glucophage) | Affected by kidney disease |
| Methotrexate (Trexall) | Affected by kidney disease |
| Probenecid | Affected by kidney disease |
| Sotalol (Betapace) | Affected by kidney disease |
| Tirofiban (Aggrastat) | Affected by kidney disease |
| Tramodol (Ultram) | Affected by kidney disease |
| Vancomycin (Vancocin) | Affected by kidney disease |
| Cholesterol lowering medications such as Lipitor, Zocor, and Pravachol | Affected by liver disease |
| Lidocaine (Xylocaine) | Affected by liver disease |
| Metformin (Glucophage) | Affected by liver disease |
| Nefazodone (Serzone) | Affected by liver disease |
| Nelfinavir (Viracept) | Affected by liver disease |
| Omeprazole (Prilosec) | Affected by liver disease |
| Ondansetron (Zofran) | Affected by liver disease |
| Paclitaxel (Taxol) | Affected by liver disease |
| Propranolol (Inderal) | Affected by liver disease |
| Ritonavir (Norvir) | Affected by liver disease |
| Tamoxifen (Nolvadex) | Affected by liver disease |
| Testosterone (AndroGel) | Affeceted by liver disease |
| Triazolam (Halcion) | Affected by liver disease |
| Trazodone | Affected by liver disease |
| Warfarin (Coumadin) | Affected by liver disease |
| Antiarrhythmics (e.g. sotalol-Betapace) | Affected by heart failure (increased risk of death) |
| Nondihydropyridinecalcium channel blockers (Diltiazem and Verapamil) | Affected by heart failure (decreased cardiac conduction) |
| metformin (Glucophage) | Increased risk of lactic acidosis |
| Thiazolidinedions, such as pioglitazone (Actos) and rosiglitazone (Avandia) | Increased sodium and water retention contributing to fluid overload and edema |
| Oral corticosteroids such as prednisone (Sterapred) | Increased sodium and water retention, contributing to fluid overload and edema |
| Estrogens and Androgens | Can precipitate acute fluid retention |
| NSAIDs such as ibuprofen (Advil, Motrin) | Potentiates peripheral edema and fluid retention |
| COX-2 Inhibitors such as celecoxib (Celebrex) | Potentiates peripheral edema and fluid retention |
| Anthracycline derivatives, such as doxorubicin (Adriamycin) and daunorubicin (Cerubidine) | Increased risk of cardiomyopathies |
| Cilostazol (Pletal) | Inhibit phosphodiesterase III resulting in decreased survival rates |
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