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Ch.13
Examples of drug to drug interactions
Term | Definition |
---|---|
What is the effect of taking NSAID's with ACE-inhibitors, resulting in increased blood pressure | Agonizes the effects of ACE inhibitors |
What is the effect of taking Amiodarone with HMG-CoA reductase inhibitors (like Atorvastatin)? | Increased risk of rhabdomyolysis and muscle weakness |
What are the effects of taking Sodium Polystyrene Sulfonate with antacids? | Binds antacid in the stomach and increases the risk of metabolic alkalosis |
What are the effects of taking aspirin with anticoagulants? | Increased risk of bleeding due to protein displacement |
What are the effects of taking oral contraceptives with antibacterials? | Decreased effectiveness of contraceptives due to increased progestin metabolism |
What are the effects of taking digoxin? | Decreased renal excretion |
What are the effects of erectile dysfunction medications with nitrates? | Low blood pressure |
What are the effects of taking fluoroquinolone antibiotics calcium, iron, and magnesium supplements | Decreased efffectiveness of the quinolone antibiotics |
What are the effects of taking selective serotonin reuptake inhibitor (SSRI) antidepressants with antimigraine medications? | Serotonin syndrome (condition characterized by muscle weakness, tremors, diarrhea, and confusion) |
What are the effects of takingiron preparations with methyldopa? | Decreased absorption of methyldopa |