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Ch.13

Examples of drug to drug interactions

TermDefinition
What is the effect of taking NSAID's with ACE-inhibitors, resulting in increased blood pressure Agonizes the effects of ACE inhibitors
What is the effect of taking Amiodarone with HMG-CoA reductase inhibitors (like Atorvastatin)? Increased risk of rhabdomyolysis and muscle weakness
What are the effects of taking Sodium Polystyrene Sulfonate with antacids? Binds antacid in the stomach and increases the risk of metabolic alkalosis
What are the effects of taking aspirin with anticoagulants? Increased risk of bleeding due to protein displacement
What are the effects of taking oral contraceptives with antibacterials? Decreased effectiveness of contraceptives due to increased progestin metabolism
What are the effects of taking digoxin? Decreased renal excretion
What are the effects of erectile dysfunction medications with nitrates? Low blood pressure
What are the effects of taking fluoroquinolone antibiotics calcium, iron, and magnesium supplements Decreased efffectiveness of the quinolone antibiotics
What are the effects of taking selective serotonin reuptake inhibitor (SSRI) antidepressants with antimigraine medications? Serotonin syndrome (condition characterized by muscle weakness, tremors, diarrhea, and confusion)
What are the effects of takingiron preparations with methyldopa? Decreased absorption of methyldopa
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