Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Pharm Exam 1 MOA
| Term | Definition |
|---|---|
| Antihistamines - H1 antagonists | Block H1 receptors resulting in bronchodilation, vasoconstriction, and decreased vascular permeability |
| Fulticasone | Decrease airway inflammation by suppressing target gene. Leads to decreased inflammatory mediators/edema/mucus production and increase airflow |
| Oxymetazoline | Constrict nasal mucosal blood vessels, decrease edema, shrink nasal mucus membranes, decrease inflammation |
| Pseudoephedrine | Constrict nasal mucosal blood vessels, decrease edema, shrink nasal mucus membranes, decrease inflammation |
| Codeine | Suppress cough reflex at level of the cough control center |
| Dextromethorphan | Suppress cough reflex at level of the cough control center |
| Bronchodilators - B2 Agonists | Bind to B2-adrenergic receptors on bronchial smooth muscle cells to cause smooth muscle relaxation |
| Ipratropium bromide | Bind to M3 muscarinic receptors on tracheal and bronchial smooth muscle and block acetylcholine from binding, ultimately decreasing smooth muscle contraction |
| Roflumilast | Increase enzyme cyclic adenosine monophosphate (cAMP). |
| Theophylline | Inhibits phosphodiesterase, leading to smooth muscle relaxation |
| Montelukast | Suppress effects of leukotrienes, reduce bronchoconstriction and inflammatory response |
| Omalizumab | Antagonism of IgE antibody |
| Prednisone | Decrease: inflammatory mediators, infiltration and inflammatory cell activity, airway edema caused by B2 agonist |
| Opioid Agonist | Activates Mu & Kappa receptors |
| Opioid Agonist-Antagonist | Partial agonist at Mu, antagonist at Kappa |
| Opioid Antagonist | Peripheral opioid receptor antagonist (Naloxone - competitive, methylnaltrexone - selective) |
| Psyllium | Swells with water, forms gel, softens stool, increases mass |
| Docusate sodium | Inhibit fluid absorption, ⬆ water and electrolytes in intestinal lumen. |
| Biscodyl | Stimulate intestinal motility. ⬆ water and electrolytes in intestinal lumen |
| Polyethylene Glycol | Non-absorbable, draws water into lumen fecal mass softens and swells lumen stretching stimulates peristalsis. |
| Loperamide | Activate Mu opioid receptors in GI tract. ⬇ intestinal motility- slow transit time. Allow ⬆ fluid and salt absorption |
| Ondansetron | Blocks serotonin receptors on vagal nerve. Increased effects with dexamethasone |
| Metoclopramide | Blocks dopamine and serotonin receptors in CTZ. Enhances acetylcholine action. Increases upper GI motility |
| Aprepitant | Blocks substance P from acting at the neurokin-1 receptor |
| Dronabinol | Related to marijuana, action is unclear |
| Scopolamine | Muscarinic antagonist |
| Antacids | Gastric alkalinizer (main), limit destruction of the gut wall, enhance mucosal production ( increase prostaglandins) |
| Omeprazole | Suppresses gastric acid secretion- most effective |
| Cimetidine | Inhibition of gastric acid secretion, stimulation of gastric mucus secretion & synthesis |
| Sucralfate | Undergoes polymerization, resulting in viscid gel. Creates protective barrier on ulcers up to 6 hrs. |
| Promethazine | Block dopamine2 receptors in CTZ |
| Dimenhydrinate | Anticholinergics- block acetylcholine and histamine receptors |
Created by:
tyolson31
Popular Pharmacology sets