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Pharm Exam 1 MOA

Antihistamines - H1 antagonists Block H1 receptors resulting in bronchodilation, vasoconstriction, and decreased vascular permeability
Fulticasone Decrease airway inflammation by suppressing target gene. Leads to decreased inflammatory mediators/edema/mucus production and increase airflow
Oxymetazoline Constrict nasal mucosal blood vessels, decrease edema, shrink nasal mucus membranes, decrease inflammation
Pseudoephedrine Constrict nasal mucosal blood vessels, decrease edema, shrink nasal mucus membranes, decrease inflammation
Codeine Suppress cough reflex at level of the cough control center
Dextromethorphan Suppress cough reflex at level of the cough control center
Bronchodilators - B2 Agonists Bind to B2-adrenergic receptors on bronchial smooth muscle cells to cause smooth muscle relaxation
Ipratropium bromide Bind to M3 muscarinic receptors on tracheal and bronchial smooth muscle and block acetylcholine from binding, ultimately decreasing smooth muscle contraction
Roflumilast Increase enzyme cyclic adenosine monophosphate (cAMP).
Theophylline Inhibits phosphodiesterase, leading to smooth muscle relaxation
Montelukast Suppress effects of leukotrienes, reduce bronchoconstriction and inflammatory response
Omalizumab Antagonism of IgE antibody
Prednisone Decrease: inflammatory mediators, infiltration and inflammatory cell activity, airway edema caused by B2 agonist
Opioid Agonist Activates Mu & Kappa receptors
Opioid Agonist-Antagonist Partial agonist at Mu, antagonist at Kappa
Opioid Antagonist Peripheral opioid receptor antagonist (Naloxone - competitive, methylnaltrexone - selective)
Psyllium Swells with water, forms gel, softens stool, increases mass
Docusate sodium Inhibit fluid absorption, ⬆ water and electrolytes in intestinal lumen.
Biscodyl Stimulate intestinal motility. ⬆ water and electrolytes in intestinal lumen
Polyethylene Glycol Non-absorbable, draws water into lumen fecal mass softens and swells lumen stretching stimulates peristalsis.
Loperamide Activate Mu opioid receptors in GI tract. ⬇ intestinal motility- slow transit time. Allow ⬆ fluid and salt absorption
Ondansetron Blocks serotonin receptors on vagal nerve. Increased effects with dexamethasone
Metoclopramide Blocks dopamine and serotonin receptors in CTZ. Enhances acetylcholine action. Increases upper GI motility
Aprepitant Blocks substance P from acting at the neurokin-1 receptor
Dronabinol Related to marijuana, action is unclear
Scopolamine Muscarinic antagonist
Antacids Gastric alkalinizer (main), limit destruction of the gut wall, enhance mucosal production ( increase prostaglandins)
Omeprazole Suppresses gastric acid secretion- most effective
Cimetidine Inhibition of gastric acid secretion, stimulation of gastric mucus secretion & synthesis
Sucralfate Undergoes polymerization, resulting in viscid gel. Creates protective barrier on ulcers up to 6 hrs.
Promethazine Block dopamine2 receptors in CTZ
Dimenhydrinate Anticholinergics- block acetylcholine and histamine receptors
Created by: tyolson31
Popular Pharmacology sets




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