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AIDS drugs part II

PI/Fusion/ccr5/intregrase

QuestionAnswer
Atazanavir Reyataz (PI)-jaundice, bradycardia, avoid PPI (few exceptions)
Darunavir Prezista (PI)-sulfamid moiety, avoid in liver patients, CYP3A4 CI
Fosamprenavir Lexiva (PI)-Sulfa-prodrug of Amprenavir
Indinavir Crixivan (PI)-Nephrolithiasis, T. bilirubin increased, alopecia, aboid antacids 1 hr, TI dosing, 48 oz/day, dec. dose with itraconazole/ketoconazole
Lopinavir/Ritonavir Kaletra (PI)-Hyperlipidemia, caution: HCV co-infection, 425 alcohol v/v, avoid voriconazole and OC, no refrigeration needed
Nelfinavir Viracept (PI)-Hyerlipidemia, increase glucose, increase transaminases, mix powder with milk, water, pudding (NOT ACIDIC), CI: 3A4, BDZ, etc.
Ritonavir Norvir (PI)-Asthenia, lipodystrophy, inc. glucose/TG, PI boosting, caps in refrigerator
Saquinavir Fortovasee/Invirase (PI)-ab. bloating, indigestion, hyperlipidemia, take WITH fatty foods; avoid rifampin-(liver toxicity)
Tipranavir Aptivus (PI)-inc. liver enzymes, hyperlipidemia, glucose
Enfuvirtide Fuzeon (Fusion inhibitors)-injection stire reaction, respiratory reactions, 45 minutes for complete dissolution
Maraviroc CCRSelzentry (CCR5 co-receptor antagonist)-DO NOT USe in dual/mixed CXCR4-tropic HIV-1 at this time, postural hypotemsion, caution: HepB/C, CVD
Raltegravir Isentress (Integrase Inhibitor)-caution UGT1A1 inhibitors like gemfibrozil, indinavir, atazanavir,....no effect CYP450
Created by: Alexia4
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