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ID 3 & 4
| Generic | Brand | Pharmacologic Category | Common Indications | Classifications | Essential Knowledge |
|---|---|---|---|---|---|
| clindamycin (PO, IV) | Cleocin | Lincosamide antibiotic | SSTI, pharyngitis Activity against: MRSA | Key Side Effects: diarrhea, Clostridioides difficile diarrhea US Boxed Warning: Clostridioides difficile-associated diarrhea (CDAD) has been reported w/ use of nearly all antibacterial agents, including clindamycin, and may range in severity from mild di | |
| sulfamethoxazole and trimethoprim (PO, IV) | Bactrim, Bactrim DS | Sulfonamide antibiotic | SSTI, Cystitis, Pyelonephritis, Opportunistic infection prophylaxis Activity against: MRSA, Enterobacteriaceae | Key Side Effects: nausea, vomiting, diarrhea, skin rashes (rarely SJS or TEN), photosensitivity, crystalluria, hyperkalemia, increased serum creatinine, hypersensitivity reactions | |
| nitrofurantoin (PO) | Macrobid | Urinary antibiotic | Cystitis Activity against: Escherichia coli | Key Side Effects: nausea, pulmonary fibrosis (chronic use) | |
| fosfomycin (PO) | Monurol | Urinary antibiotic | Cystitis Activity against: Escherichia coli | Key Side Effects: headache, nausea, diarrhea | |
| vancomycin (IV, PO) | Vancocin | Glycopeptide antibiotic | IV: SSTI, HAP, meningitis, endocarditis, CRBSI PO: CDI Activity against: MRSA, Clostridioides difficile (PO only) | Key Side Effects: nephrotoxicity, vancomycin infusion reaction, ototoxicity | |
| metronidazole | Flagyl | Antibiotic | Anaerobic infections, CDI Activity against: Bacteroides species, Clostridioides difficile | Key side Effects: nausea, metallic taste, disulfiram reaction w/ alcohol, peripheral neuropathy (long term use) | |
| mupirocin (topical) | Bactroban | Antibiotic | MRSA decolonization | Key Side Effects: no major side effects | |
| terbinafine (PO, topical) | Lamisil | Allylamine antifungal | Onychomycosis | Topical: OTC | Key Side Effects: nausea, abdominal pain, diarrhea, elevated hepatic transaminases, headache |
| acyclovir (PO, IV) | Zovirax | Antiviral | Herpes simplex virus | Key Side Effects: nausea, increased hepatic transaminases, crystalluria | |
| valacyclovir (PO) | Valtrex | Antiviral | Herpes simplex virus | Key Side Effects: nausea, increased hepatic transaminases | |
| fluconazole (PO, IV) | Diflucan | Azole antifungal | Vulvovaginal candidiasis, oropharyngeal candidiasis, invasive candidiasis | Key Side Effects: nausea, abdominal pain, diarrhea, QTc prolongation, elevated hepatic transaminases | |
| ketoconazole (PO, topical) | Nizoral | Azole antifungal | Tinea infections | Topical: OTC | Key Side Effects: nausea, abdominal pain, diarrhea, QTc prolongation, increased hepatic transaminases US Boxed Warnings: serious hepatotoxicity, including cases with a fatal outcome or requiring liver transplantation have occurred; may cause QTc prolo. |
| oseltamivir (PO) | Tamiflu | Neuraminidase inhibitor antiviral | Influenza | Key Side Effects: nausea, vomiting, neuropsychiatric events in pediatric patients (rare) | |
| nystatin (PO) | —— | Polyene antifungal | Oropharyngeal candidiasis | Key Side Effects: phlebitis, diarrhea, vomiting, anemia, fever | |
| nystatin (topical) | Nystop | Polyene antifungal | Cutaneous and mucocutaneous fungal infections | Key Side Effects: burning, itching | |
| micafungin (IV) | Mycamine | Echinocandin antifungal | Invasive candidiasis | Key Side Effects: no major side effects | |
| betamethasone and clotrimazole (topical) | Lotrisone | Glucocorticoid and Azole antifungal | Cutaneous fungal infections | Key Side Effects: burning, itching, dryness, skin atrophy | |
| tobramycin (IV, inhaled) | Tobi (inhaled) | Aminoglycoside antibiotic | HAP, Cystic fibrosis (nebulized only) Activity against: Escherichia coli, Pseudomonas aeruginosa | Key Side Effects: nephrotoxicity, ototoxicity | |
| neomycin + polymyxin B + bacitracin (topical, ophthalmic) | Topical: Neosporin Ophthalmic: Neo-Polycin | Topical antibiotic | Topical infection prevention Ocular infections | Neosporin: OTC | Key Side Effects: reddening, itching |
| nirmatrelvir + ritonavir (PO) | Paxlovid | Antiviral | COVID-19 | Key Side Effects: diarrhea, dysgeusia US Boxed Warnings: significant drug interactions; strong CYP3A inhibitor | |
| remdesivir (IV) | Veklury | Antiviral | COVID-19 | Key Side Effects: hyperglycemia, renal impairment | |
| emtricitabine + tenofovir disoproxil fumarate (PO) | Truvada | Nucleoside/Nucleotide Reverse Transcriptase Inhibitor (NRTI) | HIV infection, PreP, PEP | Key Side Effects: decreased bone mineral density, kidney injury, nausea, diarrhea US Boxed Warnings: post treatment acute exacerbation of hepatitis B, risk of drug resistance w/ use for preexposure prophylaxis | |
| emtricitabine (NRTI) + tenofovir alafenamide (NRTI) + bictegravir (INSTI) (PO) | Biktarvy | Nuceloside/ Nucleotide Reverse Transcriptase Inhibitor (NRTI) and Integrase strand transfer inhibitor (INSTI) | HIV infection | Key Side Effects: increased serum bilirubin, headache, weight gain, insomnia, diarrhea, nausea US Boxed Warnings: post treatment acute exacerbation of hepatitis B |