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Musculoskeletal

GenericBrandPharmacologic CategoryIndicationSide Effects
Tizanidine (PO) Zanaflex Alpha2 agonist Spasticity drowsiness, hypotension, dizziness, xerostomia, weakness
Hydroxychloroquine (PO) Plaquenil Aminoquinolone RA, SLE (systemic lupus erythematosus, malaria retinal toxicity, rash, diarrhea Notes: use associated w/ cardiomyopathy, bone marrow suppression & neuromuscular effects (myopathy, palsies, & progressive weakness)
Colchicine (PO) Colcrys Antigout agent Gout diarrhea, nausea, vomiting, bone marrow suppression, myopathy (including rhabdomyolysis)
Diclofenac (PO) Voltaren NSAID OA, RA, acute pain diarrhea, dyspepsia, abdominal pain, nausea flatulence, may reduce renal blood flow/ fxn (avoid w/ renal disease, HF & cirrhosis) BW: may increase risk of CV events, MI & stroke; may increase risk for serious GI ADRs (ulceration, bleeding & perforation)
Ibuprofen (PO)* Motrin, Advil NSAID OA, RA, acute pain diarrhea, dyspepsia, abdominal pain, nausea flatulence, may reduce renal blood flow/ fxn (avoid w/ renal disease, HF & cirrhosis) BW: may increase risk of CV events, MI & stroke; may increase risk for serious GI ADRs (ulceration, bleeding & perforation)
Meloxicam (PO) Mobic NSAID OA, RA, acute pain diarrhea, dyspepsia, abdominal pain, nausea flatulence, may reduce renal blood flow/ fxn (avoid w/ renal disease, HF & cirrhosis) BW: may increase risk of CV events, MI & stroke; may increase risk for serious GI ADRs (ulceration, bleeding & perforation)
Indomethacin (PO) Indocin NSAID OA, RA, acute pain, gout diarrhea, dyspepsia, abdominal pain, nausea flatulence, may reduce renal blood flow/ fxn (avoid w/ renal disease, HF & cirrhosis) BW: may increase risk of CV events, MI & stroke; may increase risk for serious GI ADRs (ulceration, bleeding & perforation)
Naproxen (PO) * Naprosyn, Anaprox, Aleve NSAID OA, RA, acute pain, gout diarrhea, dyspepsia, abdominal pain, nausea flatulence, may reduce renal blood flow/ fxn (avoid w/ renal disease, HF & cirrhosis) BW: may increase risk of CV events, MI & stroke; may increase risk for serious GI ADRs (ulceration, bleeding & perforation)
Ketorolac (PO, IV) Toradol NSAID Pain diarrhea, dyspepsia, abdominal pain, nausea flatulence, may reduce renal blood flow/ fxn BW: may increase risk of CV events, MI & stroke; may increase risk for serious GI ADRs (ulceration, bleeding & perforation) *short term use (≤ 5 days)
Celecoxib (PO) Celebrex NSAID, COX-2 selective OA, RA, acute pain diarrhea, dyspepsia, abdominal pain, nausea flatulence, may reduce renal blood flow/ fxn (avoid w/ renal disease, HF & cirrhosis) BW: may increase risk of CV events, MI & stroke; may increase risk for serious GI ADRs (ulceration, bleeding & perforation)
Diclofenac (topical) * Voltaren Gel NSAID OA pruritus, rash
Cyclobenzaprine (PO) Flexeril Skeletal muscle relaxant Muscle spasm drowsiness, dizziness, xerostomia, fatigue Notes: use may cause prolonged cardiac arrhythmias & tachycardia; CI w/in 14 days of MAOI inhibitor therapy
Baclofen (PO) N/A Skeletal muscle relaxant Spasticity drowsiness
Carisoprodol (PO) Soma Skeletal muscle relaxant Muscle spasm drowsiness Notes: drug abuse potential
Methocarbamol (PO) Robaxin Skeletal muscle relaxant Muscle spasm drowsiness
Metaxalone (PO) Skelaxin Skeletal muscle relaxant Muscle spasm drowsiness
Allopurinol (PO) Zyloprim Xanthine oxidase Inhibitor Gout diarrhea, nausea, rash, leukopenia, thrombocytopenia Notes: rare association w/ severe/potentially fatal allopurinol hypersensitivity syndrome (risk highest in certain Asian pop.)
Succinylcholine (IV) Anectine Depolarizing neuromuscular blocking agent Neuromuscular blockade for intubation/ procedures hyperkalemia, myalgia, malignant hyperthermia (rare) Boxed Warning: acute rhabdomyolysis & hyperkalemia leading to cardiac arrest & death in pediatric pts w/ undiagnosed skeletal muscle disease
Lidocaine (transdermal *, IV) Transdermal: Lidoderm IV: Xylocaine Transdermal: topical analgesic IV: antiarrhythmic Transdermal: pain, IV: ventricular arrhythmias transdermal: dermatitis, erythema, urticaria, skin depigmentation, skin edema IV: bradycardia Notes: patch can be cut & can be in place for up to 12 hours in 24h period
Created by: Aware19
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