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ADHD IOS 8-4
ADHD
Question | Answer |
---|---|
Molecular Pathophysiology suggests | Hypodopamergic networks |
Potential decrease in brain | DA transporter, D4 and D5 recptors, Dopamine-B-hydroxylase, and abnormal SNP25 |
Most relevant to ADHD is the pathway | Mesocortical DA pathway |
Mesocortical DA pathway | Cell bodies arise in the ventral tegmental area and project to areas of the cerebral cortex. |
DA does what to a signal | Enhances focus, serial learning,executive functioning |
ADHA brain size | Smaller than othe people |
DA neurotransmission relative to ADHD | Ventral tegmental area (synthesized) and move to mesocortical pathway |
Norepinephrine relative to ADHD | NE filters noise and inhibits impulsive behavior |
DS-IV criteria | 6 or more of inattention (9) , impulsive (3), or Hyperactivity (6) |
Medication to treat ADHD | Methylphenidate (Concerta), Dextroamphetamine, Amphetamine, Atomoxetine |
ADHD 1st Line | Methylphenidate (Concerta), Amphatamines (Adderall XR) |
Amphetamines MOA | Inhibits Da reuptake in synaptic cleft, Increase DA release, Blcok uptake into vesicle in pre-synaptic neuron |
Methyphenidate MOA | Inhibits DA uptake in synaptic cleft |