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Pharmacology test 2

Pharmacology reproductive health drugs

QuestionAnswer
Treat Infertility drugs that Control ovarian stimulation
Control Ovarian stimulation Menotropins and Human chorionic gonadotropins
Mechanism of action of drugs that control ovarian stimulation promotes ovulation by replacing LH and FSH ( human menopausal gonadotropin )
Adverse effects of drugs that COS Ovarian hyperstimulation syndrome; enlargement or ovaries and multiple births administered SubQ or IM
Uterine relaxants Terbutaline Nifedipine Magnesium Sulfate
Uterine stimulants Oxytocin Misoprostol
Agents that prevent hemorrhage oxytocin/ misoprostol
Terbutaline delays labor for about 48 hrs by agonizing beta 2 in the uterine smooth muscle
Terbutaline adverse effects Mom and baby tachycardia, pulmonary edema and hyperglycemia
Nifedipine Delays labor by inhibiting calcium channels in uterine smooth muscle; adverse effects are rare
Magnesium sulfate Neuroprotection to reduce the risk of preterm associated cerebral palsy for baby and seizures associated with preeclampsia/eclampsia for mom, inhibits ACH release at the neuromuscular junction
Mag Sulfate adverse effects Mom: transient tachycardia, flushing, headache, dizziness and nausea Contradicted in myasthenia gravis pts, renal failure, and hypocalcimia baby- may cause hypotonia muscle weakness
Oxytocin Pitocin stimulate uterine contractions and milk production drug of choice for induction cervical ripening must be complete; fetal lungs must be mature, fetus must be facing down and facing back
oxytocin contradictions/ interrupt infusion resting intrauterine pressure greater than 15-20 mmhg individual contractions longer than 1 minute contractions less than 2 minutes apart high fetal HR or rhythm changes
Misoprostol and dinoprostone MOA Promotes cervical ripening and uterine contractions by mimicking prostaglandins Drug of choice for cervical ripening
Testosterone, fluoxymesterone, oxandronelone male hormone replacement therapy MOB replaces testosterone
Adverse effects of male hormone replacement therapy edema prostate cancer hepatotoxicity- educate on liver dysfunction virilization unintended transfer teratogenesis- no for pregnant pts
Anabolic steroids nandrolone, stanozolol, methenolone
Anabolic steroid's use used to illegally enhance athletic performance promotes growth of skeletal muscle synthesis of erythropoiten to produce red blood cells
steroids adverse effects hypertension, suppresion of release of FH and FSH-testicular shrinkage Hepatotoxicity renal damage increase in LDL
Tx for erectile dysfunction PDE5 inhibitors
Sildenafil Viagra promotes vasodilation by inhibiting PDE5 requires a stimulus
slidenafil adverse affects Hypotension due to vasodilation Priapism- painful erection greater than 6 hrs rare sudden hearing loss and headache
Sildenafil drug interactions Nitrates- nitroglycerin both drugs increase cGMP and promote vasodilation when combined alpha blockers also cause dilation (prazosin)
Tx for BPH 5 alpha reductase inhibitors Alpha 1 adrenergic antagonists PDE5 inhibitors Anticholinergics Botulinum toxin- directly injected in the prostate
Dutasteride; finasteride 5 alpha reductase inhibitors reduces prostate size by inhibiting 5 alpha reductase which causes epithelial tissue to regress
Dutasteride adverse effects decreased ejaculate volume and libido, gynecomastia risk of prostate cancer teratogenic to male fetus
Created by: gabby025
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