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Cholinergic Drugs

TermDefinition
Pilocarpine (Isopto,Carpine) DIRECT (REVERSIBLE) INDC : Glaucoma MOA : Short Acting - Bind via H-Bonds MOA: Long Acting - Ester and Hydroxyl Group Bonds ADR: Diarrhea, Urination, Miosis, Bronchospams, Bradycardia, Excite muscle/cns, Emesis, Lacrimation, Lethargy, Salivate
Pilocarpine (Salagen) DIRECT (REVERSIBLE) INDC : Dry Mouth MOA : Short Acting - Bind via H-Bonds MOA: Long Acting - Ester and Hydroxyl Group Bonds ADR: Diarrhea, Urination, Miosis, Bronchospams, Bradycardia, Excite muscle/cns, Emesis, Lacrimation, Lethargy, Salivate
Bethanechol (Urecholine) DIRECT (REVERSIBLE) INDC : Postoperative Illeus / Urinary Retention MOA : Short Acting - Bind via H-Bonds MOA: Long Acting - Ester and Hydroxyl Group Bonds ADR: D.U.M.B.E.E.L.L.S
Carbachol (Miostat, Carbastat) DIRECT (REVERSIBLE) INDC : Glaucoma MOA : Short Acting - Bind via H-Bonds MOA: Long Acting - Ester and Hydroxyl Group Bonds ADR: Diarrhea, Urination, Miosis, Bronchospams, Bradycardia, Excite muscle/cns, Emesis, Lacrimation, Lethargy, Salivate
Cevimeline (Evoxac) DIRECT (REVERSIBLE) INDC : Dry Mouth (Xerostomia) MOA : Short Acting - Bind via H-Bonds MOA: Long Acting - Ester and Hydroxyl Group Bonds ADR: D.U.M.B.E.E.L.L
Endrophonium (Tensilon) INDIRECT AChE INHIBITOR INDC : Cholinergic VS Myasthenic Crisis MOA : Reversal of Neuromuscular Blockade ADR: Diarrhea, Urination, Miosis, Bronchospasms, Bradycardia, Excite muscle/cns, Emesis, Lacrimation, Lethargy, Salivate
Neostigmine (Prostigmin) INDIRECT AChE INHIBITOR INDC : Myasthenia Gravis MOA : Reversal of Neuromuscular Blockade ADR: Diarrhea, Urination, Miosis, Bronchospams, Bradycardia, Excite muscle/cns, Emesis, Lacrimation, Lethargy, Salivate
Paraoxon Echothiophate Malathion Sarin Soman ORGANOPHOSPHATES - INDIRECT // IRREVERSIBLE INDC: Insecticides & Herbicides MOA: Serine Residues > electrophilic phosphate = serine phosphate, can’t Hydrolyze ADR: D.U.M.B.E.E.L.L.S
Nicotine Nicotinic (AGONIST) INDC : Tobacco Cessation Program MOA: CNS : Stimulate Nn of ANS ganglia and Adrenal Medulla MOA: PNS: Agonist of presynaptic A4B2 Nicotine receptors on nucleus accumbens ADR: D.U.M.B.E.E.L.L.S
Varenicline (Chantix) Nicotinic (AGONIST) INDC : Tobacco Cessation Program MOA: Selectively Binds to A4B2 Nicotine Receptors MOA: Prevents Large Amounts of DA ADR: D.U.M.B.E.E.L.L.S + Nausea Insomnia, suicide, hypersensitivity
Created by: kimi_neria
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