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Ch11 Geriatric

Pharmacology

QuestionAnswer
NAME THE 5 LAB TEST THAT ARE USED TO ADJUST THE MEDS. FOR GERIATRIC PATIENTS SERUM PROTEIN, ELECTROLYTES, LIVER ENZYMES, BUN-BLOOD UREA NITROGEN AND CREATININE
WHEN 1ST PRESCRIBING MEDS TO OLDER PATIENTS WHAT COULD HELP PREVENT OVERDOSE OR DRUG COMPLICATIONS? START WITH A LOW DOSE THEN GRADUALLY INCREASE IT ACCORDING TO TOLERANCE AND REACTION.
POLYPHARMACY ADMINISTERING MANY DRUGS TOGETHER
WHAT SYSTOMS CAN COME FROM POLYPHARMACY? CONFUSION, FALLS, MALNUTRITION, RENAL AND LIVER DYSFUNCTION
EFFECTS OF SLOWED ABSORPTION IN THE GERITRIC POPULATION DECREASED GASTRIC ACIDITY(CAUSES DRUGS TO BE POORLY ABSORBED), BLOOD FLOW TO GI TRACT, CARDIAC OUTPUT, PERISTALSIS IN GI, GASTRIC EMPTYING.
EFFECTS SLOWED DRUG DISTRIBUTION? LOSS OF BODY WATER WHICH CAUSES FAT SOLUBLE DRUGS TO BE MORE READILY ABSORBED AND DECREASING THEIR EFFICENCY. LESS ALBUMIN PROTEIN AND THEREFORE MORE FREE DRUG IN SYSTEM.
DECREASED METABOLISM EFFECTS FROM WHAT? LESS HEPATIC ENZYMES, BLOOD FLOW AND LIVER FUNTION. THESE CHANGES INCREASE THE HALF-LIFE OF DRUGS AND CAN CAUSE TOXICITY WHEN DRUGS ACCUMULATE.
DECREASED EXCRETION CAUSED BY WHAT? DECREASED CARDIAC OUPUT AND BLOODFLOW OF CIRCULATORY SYS. AFFECTING BLOOD FLOW TO LIVER AND KIDNEYS.
WHAT lab tests asses for kindney function? BUN, serum creatinine,creatinine clearance.
in the elderly a decrease in creatinine levels can indicate what? slowed renal function!( elderly have less muscle mass and creatinine is byproduct of muscle catabolism.)
in the middle adult an increase in creatinine would indicate what? decreased renal function
when elderly have liver and kidney dysfunction what happens to drug efficacy or its ability to produce specific results? its effiacy is decreased so the drug dose would need to be decreased also to prevent drug accumulation and toxicity from occuring.
the factors that add to adverse rxn's in elderly are? less protein binding sites,less 1-st pass metabolism effect which causes more free drug in sys., longer half life of drug because of liver and kidney dysfunction.
How a drug interacts at the receptor site or at the target organ is called?(these are increased or decreased responses in the elderly) Pharmacodynamics
Orthostatic Hypotension rapid decrease in blood pressure when standing quickly(occur when vasodilator doesn't produce quick enough response of dialating or opening blood vessesls)
Created by: VRoberts
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