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Ch11 Geriatric
Pharmacology
| Question | Answer |
|---|---|
| NAME THE 5 LAB TEST THAT ARE USED TO ADJUST THE MEDS. FOR GERIATRIC PATIENTS | SERUM PROTEIN, ELECTROLYTES, LIVER ENZYMES, BUN-BLOOD UREA NITROGEN AND CREATININE |
| WHEN 1ST PRESCRIBING MEDS TO OLDER PATIENTS WHAT COULD HELP PREVENT OVERDOSE OR DRUG COMPLICATIONS? | START WITH A LOW DOSE THEN GRADUALLY INCREASE IT ACCORDING TO TOLERANCE AND REACTION. |
| POLYPHARMACY | ADMINISTERING MANY DRUGS TOGETHER |
| WHAT SYSTOMS CAN COME FROM POLYPHARMACY? | CONFUSION, FALLS, MALNUTRITION, RENAL AND LIVER DYSFUNCTION |
| EFFECTS OF SLOWED ABSORPTION IN THE GERITRIC POPULATION | DECREASED GASTRIC ACIDITY(CAUSES DRUGS TO BE POORLY ABSORBED), BLOOD FLOW TO GI TRACT, CARDIAC OUTPUT, PERISTALSIS IN GI, GASTRIC EMPTYING. |
| EFFECTS SLOWED DRUG DISTRIBUTION? | LOSS OF BODY WATER WHICH CAUSES FAT SOLUBLE DRUGS TO BE MORE READILY ABSORBED AND DECREASING THEIR EFFICENCY. LESS ALBUMIN PROTEIN AND THEREFORE MORE FREE DRUG IN SYSTEM. |
| DECREASED METABOLISM EFFECTS FROM WHAT? | LESS HEPATIC ENZYMES, BLOOD FLOW AND LIVER FUNTION. THESE CHANGES INCREASE THE HALF-LIFE OF DRUGS AND CAN CAUSE TOXICITY WHEN DRUGS ACCUMULATE. |
| DECREASED EXCRETION CAUSED BY WHAT? | DECREASED CARDIAC OUPUT AND BLOODFLOW OF CIRCULATORY SYS. AFFECTING BLOOD FLOW TO LIVER AND KIDNEYS. |
| WHAT lab tests asses for kindney function? | BUN, serum creatinine,creatinine clearance. |
| in the elderly a decrease in creatinine levels can indicate what? | slowed renal function!( elderly have less muscle mass and creatinine is byproduct of muscle catabolism.) |
| in the middle adult an increase in creatinine would indicate what? | decreased renal function |
| when elderly have liver and kidney dysfunction what happens to drug efficacy or its ability to produce specific results? | its effiacy is decreased so the drug dose would need to be decreased also to prevent drug accumulation and toxicity from occuring. |
| the factors that add to adverse rxn's in elderly are? | less protein binding sites,less 1-st pass metabolism effect which causes more free drug in sys., longer half life of drug because of liver and kidney dysfunction. |
| How a drug interacts at the receptor site or at the target organ is called?(these are increased or decreased responses in the elderly) | Pharmacodynamics |
| Orthostatic Hypotension | rapid decrease in blood pressure when standing quickly(occur when vasodilator doesn't produce quick enough response of dialating or opening blood vessesls) |