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Pharm Depression

QuestionAnswer
What do TCAs work on? Epi & norepi
ADR of TCAs? sexual dysfunction
Tertiary Amines Elavil, Anafril, Tofranil, Sinequan
Elavil MOA increase synaptic conc of seratonin &/or norepi in CNS by inhibiting their reuptake
Anafril MOA affect seratonin uptake while its active metabolite, desmethyclomipramine, affects NE uptake
Tofranil MOA same as elavil & also desnsitizes adenylcyclase, down regulation of beta adrenergic receptors & seratonin receptors
Sinequan MOA same as elavil - very sedating (anti-histamine like, will stop itching too)
Secondary Amines Norpramin, Nortriptyline
Norpramin & Nortriptyline MOA same as tofranil
SSRI MOA inhibit CNS seratonin reuptake w/ minimal or no NE effect or dopamine, no significant binding to alpha adrenergic, histamine, or cholinergic receptors
SSRIs prozac, zoloft, paxil, celexa, luvox
Prozac, zoloft, paxil, & celexa ADR sexual dysfunction
which was the first SSRI? prozac
SNRIs effexor & cymbalta
Effexor MOA @ low doses - seratonin effects, no pain help, high does = seratongeric & NE effect and can help w/ pain
Cymbalta MOA seratonergic & NE effects @ regular dose, will help w/ pain
Seratonin Syndrome hyperthermia, rigidity, myoclonus, mental status changes, N - seen when several meds are combined (esp @ high doses), TCA, SSRI, imitrex, ultram
Atypicals Wellbutrin, Remeron, Desryel
Wellbutrin also used for tobacco cessation
Remeron MOA tetracyclic antidepressant, central presynaptic alpha 2 adrenergic antagonist effects when increase NE & seratonin
Desryel MOA inhibit reuptake of seratonin & NE by presynaptic neuronal membrane & desensitization of adenyl receptors & down regulation of seratonin receptors
MAOIs can't take w/ other tx, DANGEROUS, MAOI breaks down epi, norepi, dopamine & seratonin - need tyramine diet & 2-12wk washout period
MAOIs Nardil, parnate
St. John's Wart like an MAOI and similar to TCA
Created by: Marywood
Popular Pharmacology sets

 

 



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