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Pharm Anticonvusants

QuestionAnswer
DOC for Status Epilepticus IV Valium or ativan
Hydantoins phenytoin & cerebyx
MOA hydantoins stop sz from spreading when gets into motor cortex & antiarrhythmic
hydantoins contraindicated pure absence szs
warnings w/ hydantoins abrupt w/drawl = SE, acute ETOH inc levels, chronic ETOH dec levels, d/c if skin rash
special instruction when taking hydantoins with Ca separate times of ingestion to prevent absorption problems
succinimies - zarontin DOC for what? and MOA DOC childhood absence szs, MOA - selectively depresses low frequency inhibitory pathway which decreases response to low frequency repetitive stimulation
Neurontin MOA GABA analog synthesized to cross BBB, no direct GABA mimetic action, mechanism unknown
Lamictal MOA unknown, might block Na & Ca channels, inhibit glutamase release - NO ONE UNDER 16
Valproic Acid MOA unknown
Valproic Acid Warnings fatal hepatotoxicity - decreases w/ age, in 1st 6mo of tx, LFTs frequently & stop w/ hepatic dysfunction - also NTDs if taken in 1st trimester
Tegretol MOA limit sz propagation by blocking postsynaptic trasmission
Tegretol Warnings benign leukopenia - do cbc w/ diff @ baseline & q3mo x 1yr
Phenobarbitol MOA controlled substance, decreases monosynaptic & postsynaptic transmission leading to a decrease in excitability of entire nerve
Mysolin MOA phenobarb analog, has active metabolites, PEMA
Topomoax MOA adjunctive tx for partial, MOA unknown - might block Na & enhance Cl channel (DI contraceptives)
Felbatol MOA unknown, weak inhibitory effects on GABA receptor binding sites
Felbatol ADR aplastic anemia, hepatic failure (rare)
Keppra ADR suicide attempts, adjunctive tx partial szs
Oxcarbazepine MOA this & its metabolite, MHD, have effects on Na channels (& possibly K & Ca channels) - DI contraceptives
Gabitril & Zonegran MOA unknown
Valium MOA suppresses spread of sz activity but doesn't abolish abnormal discharge from a focus
ADR of Valium addiction
Created by: Marywood
Popular Pharmacology sets

 

 



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