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Antihyperlipidemic
| Question | Answer |
|---|---|
| HMG-CoA REDUCTASE INHIBITORS | referred to as statins, inhibiting the manufacturing of cholesterol,or promoting the breakdown of cholesterol, LDLs and serum triglycerides |
| HMG-CoA REDUCTASE INHIBITORS | treatment of hyperlipidemia,primary prevention of coronary events, secondary prevention of cardiovascular events |
| HMG-CoA REDUCTASE INHIBITORS | side effects include CNS- headache, dizziness, insomnia, GI- flatulance, abdominal pain, cramping, constipation, nausea |
| HMG-CoA REDUCTASE INHIBITORS | contraindicated in those with hypersensitivity to drug, serious liver disorders and pregnancy(catefory X)and lactaition |
| HMG-CoA REDUCTASE INHIBITORS | use catiously with history of alcoholism, acute infection, hypotension, trauma, endocrine disorders, visual disturbances, and myopathy |
| BILE ACID RESINS | bind to bile acids to form an insoluble substance that cannot be absorbed by the intestine |
| BILE ACID RESINS | hyperlipidemia and pruritus associated with partial biliary obstruction |
| BILE ACID RESINS | side effects- constipation, aggravation of hemorrhoids, abdominal cramps, flatulance, nausea, increased bleeding tendencies related to vit K malabsorption, and vit B & D deficiencies |
| BILE ACID RESINS | contraindicated in patients with hypersensitivity to drug, and those with complete biliary obstruction |
| BILE ACID RESINS | use cautiously with liver and kidney disease, during pregnancy(category C)& lactation(decreased absorption of vitamins may affect the infant) |
| FIBRIC ACID DERIVATIVES | also known as fibrate, Clofibrate, Fenofibrate, Gemfibrozil |
| FIBRIC ACID DERIVATIVES | uses vary depending on the drug |
| FIBRIC ACID DERIVATIVES | side effects- nausea, vomiting, GI upset, diarrhea, cholelithiasis(stones in the gallbladder) and cholecystitis(inflammation of the gallbladder) |
| FIBRIC ACID DERIVATIVES | contraindcated in patients with hypersensitivity to drug, with significant hepatic or renal dysfunction or primary biliary cirrosis cause these drugs may increase the already elevated cholesterol |
| FIBRIC ACID DERIVATIVES | use cautiously during pregnancy(category C), not during lactation, or in patients with peptic ulcer disease or diabetes |
| MISC ANTIHYPERLIPIDEMIC DRUGS | includeniacin and ezetimibe |
| MISC ANTIHYPERLIPIDEMIC DRUGS | side effects- GI-nausea, vomiting, abdominal pain, diarrhea other- severe, generalized flushing of the skin, sensation of warmth, severe itching or tingling |
| MISC ANTIHYPERLIPIDEMIC DRUGS | contraindcated in patients with hypersensitivity tp niacin, active peptic ulcer, hepatic dysfunction and arterial bleeding |
| MISC ANTIHYPERLIPIDEMIC DRUGS | use cautiously with renal dysfunction, high alcohol consumption, unstable angina, gout and pregnancy(category C) and lactating women should not use ezetimibe |
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