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B Pharmaco Ex2
PCOL Adrenergic Drug/ Extra Key Info
Drug | Extra/ Key Info |
---|---|
Phenylephrine | Nasal decongestant & Ophthalmics (Mydriasis) Down Regulation-->Rebound congestion Avoid HTN patients |
Cocaine | Used with Lidocaine to control Arrhythmias (Na+ channel blocker) |
Dextroamphetamine/Amphetamine (Addy) Methylphenidate (Concerta, Ritalin) Lisdexamphetamine (Vyvanse) Dexmethylphenidate (Focalin) | ADHD |
Phenelzine | Inhibits breakdown of NE Serious ADR--> HTN crisis due to dietary Tyramine |
Selegiline Rasagiline | Inhibits breakdown of NE Used for Depression & Parkinson's |
Prazosin Terazosin (Hytrin) Doxazosin (Cardura) Tamsulosin (Flomax) -> alpha1a | Treat HTN, BPH, & PTSD (only on of the drugs) Decrease Preload and Afterload (blood vessels) |
Phenoxybenzamine | Used for HTN Crisis caused by Phenelzine (short term control) Longer duration of action (irreversible-->highest affinity for a1) |
Mirtazapine (Remeron) | Used for MDD Rare side effect: Agranulocytosis a2's are located in small blood vessels and cause vasoconstriction-->antagonist will cause vasodilation-->Peripheral edema |
Clonidine (Catapres) Brimonidine (Alphagan P) Tizanidine (Zanaflex) Guanfacine (Intuniv) Dexmedetomidine (Precedex) | HTN Crisis can occur if taken off drug abruptly due to Up-Regulation of receptors. |