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Pharmacology test 2

Neuromuscular

DrugMOASOASide effects/ADRExtra/key information
Acetylcholine nicotinic and muscarinic Depolarizing agent all over body DUMBELSS Diarrhea, urination, miosis, bradycardia, bronchial constriction, emesis, lacrimation, salivation, stimulation (CNS)
Chantix a4/b2 Nn partial agonist CNS (Nn) headache, insomnia, suicidal thoughts, depression, flatuence FDA black box warning of mood
succinylcholine depolarizing agent (neuromuscular blockade)-nictinic NMJ (Nm) Can affect PNS/SNS ganglia (Nn) NMJ Paralysis Hyperkalemia, HTN and arrythmias, muscle pain, hyperthermia Phase 1: binds to ALL Ach binding space and keeps all Na channels open (cannot repolarize) Phase 2: blocks Na channels:gets stuck (can't depolarize)
Physostigmine Cholinesterase Inhibitor (AChE Antagonist) CNS BBB DUMBELSS Penetrates CNS / cross BBB Antidote for anti-muscarinic poisoning (Atropine overdose)
Donepezil (Aricept) Rivastigmine (Exelon) Galantamine Cholinesterase Inhibitor (AChE Antagonist) CNS BBB DUMBELSS Lipophilic cross BBB Used for dementia / Alzheimer’s Longer t1/2 than Physostigmine
PyriDOstigmine Neostigmine Cholinesterase Inhibitor (AChE Antagonist) NMJ(targeting periphery) DUMBELSS DO NOT cross BBB stays in the periphery Reverse the effects of Curare / treatment of myasthenia gravis
Edrophonium Cholinesterase Inhibitor (AChE Antagonist) NMJ(targeting periphery) DUMBELSS Used for diagnosis of myasthenia gravis or medication dose adjustments Short duration of action/reversible
Echothiophate Organophosphate inhibitor of acetylcholinesterase enzyme M3 receptor in ciliary muscle (eye) Miosis and blurred vision, lacrimation, stinging / redness of eye Ophthalmology treatment glaucoma
Botulinum Toxin (Botox) Prevent ACh release Presynaptic terminal Muscle relaxation Cleaves sites on SNARE protein
Curare & Curare like Rocuronium NON-depolarizing agent Direct competitive antagonist  Binds to Ach binding space NMJ-Nm NMJ Paralysis Histamine release, hypotension & tachycardia No CNS effect Doesn’t allow Ach to bind; keeps channels closed
Created by: denaeprice
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