Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Ch 21 Cancer
Antineoplastic Agents
| Question | Answer |
|---|---|
| What are the 5 phases of the cell cycle? | first growth phase (G1), synthesis (S1), second growth phase (G2), mitosis (M), and resting phase (G0) |
| How are agents most commonly given? | In combinations of 2 or more at a time |
| How do Antimetabolites prevent cancer cell growth? | By affecting DNA production |
| What are 7 therapeutic uses of the Antimetabolite Methotrexate (MTX)? | Used for acute lymphoblastic leukemia, meningeal leukemia, head and neck cancers, rheumatoid arthritis, psoriasis, ectopic pregnancy, and inflammatory bowel disease. |
| What are 3 drug interactions with the Antimetabolite Methotrexate (MTX)? | Avoid alcohol, aspirin, NSAIDs |
| What are hormonal agents? | A class of heterogenous compounds that have various effects on cells. |
| How do hormonal agents work? | They either block hormone production or block hormone action. |
| Hormonal agents' action on malignant cells is _________ selective. They are the _____________ toxic of the anticancer medications. | highly, least |
| What Antitumor Antibiotic is the single most active agent against breast cancer? | Doxorubicin |
| What are the adverse effects of the Antitumor Antibiotic Doxorubicin? | Serious, irreversible myocardial toxicity, hypertension, and hypotension |
| Describe the Antitumor Plicamycin? | A cytotoxic, antibiotic, and antineoplastic agent |
| What is the mechanism of action for the Antitumor Plicamycin? | Appears to block the hypercalcemic action of vitamin D and may inhibit the effect of parathyroid hormone on bone cells (osteoclasts) |
| What are the adverse effects of the Alkylating Agent Cyclophosphamide, including long-term toxicity? | anorexia, vomiting, alopecia (hair loss), leukopenia, and potentially serious hemorrhagic cystitis. Long-term toxicity includes sterility and carcinogenesis. |
| How is the Alkylating Agent Melphalan well absorbed? | Orally |
| What is the major use for the Alkylating Agent Melphalan? | The treatment of multiple myeloma (a special cancer of the white blood cells that causes abnormal plasma cells to develop) |
| The Alkylating Agent Melphalan is usually used in combination with: | Prednisone |
| What are other two uses for the Alkylating Agent Melphalan? | breast cancer and melanoma |
| This is a Mitotic Inhibitor (Plant Alkaloid) and antineoplastic agent: | Etiposide |
| What is the major use for the Mitotic Inhibitor (Plant Alkaloid) Etiposode? | Treatment of refractory testicular tumors as part of combination therapy. |
| Immunosuppression has what harmful effects? | Makes the patient more vulnerable to infection. |
| About _____% of patients with cancer die of intercurrent infections rather than from terminal phases of cancer. | 50% |
Created by:
1531944093
Popular Pharmacology sets