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Orange Block 6 & 7
Bisphosphonate, Gout medications, etc.
| Question | Answer |
|---|---|
| Ends in -dronate | Bisphosphonate |
| Antiresorptive | Bisphosphonate MOA |
| Inhibits Osteoclast activity | Bisphosphonate MOA |
| Suppresses bone turnover & bone loss | Bisphosphonate MOA |
| Take on a n empty stomach, with a full glass of water, don't lay down for at least 30 minutes after taking, and avoid dairy, iron, and antacids. | Aux labels for Bisphosphonates |
| Painful swallowing, heartburn, N/V/D, and can cause damage to the esophagus | Common Adverse Reactions of Bisphosphonates |
| alendronate | Fosamax |
| 10mg tabs - Once daily 70mg tabs - Once weekly | Fosamax |
| risedronate | Actonel |
| 35mg tabs - Once weekly 150mg tabs - Once monthly | Actonel |
| allopurinol | Zyloprim |
| 100mg, 200mg, 300mg tabs Uric acid synthesis inhibitor May take with food Take with glass of water Used to treat gout | Zyloprim |
| probenecid | Benuryl |
| 500mg tabs Uricosuric Take with food Take with water Used to treat gout | Benuryl |
| 0.6mg tabs Anti-inflammatory Take with water Avoid alcohol Used to treat gout | colchicine |
| indomethacin | Indocid |
| 25mg, 50mg caps NSAID Take with water Take with food Used to treat gout | Indocid |
| naproxen | Naprosyn |
| 250mg, 375mg, 500mg tabs NSAID Take with water Take with food Used to treat gout | Naprosyn |
| Used to treat GERD, Ulcers | Prokinetics |
| Increased peristalsis Speeds gastric emptying Improves lower esophageal sphincter tone (LES) | MOA of Prokinetics |
| Commonly dosed TID before meals and HS | Prokinetics |
| metoclopramide | Maxeran |
| 50mg, 10mg tabs Oral liquid | Maxeran |
| domperidone | Motilium |
| 10mg tabs | Motilium |
| Used to treat constipation | Laxatives |
| Non-absorbable substances that pull water into lumen Increase stool frequency & consistency | MOA of Osmotic Laxatives |
| Increases water & bulk of stool Improves stool consistency Patient must take with lots of water | MOA of Bulk Forming Laxatives |
| Increases GI motility | MOA of Stimulant Laxatives |
| Commonly dosed PRN | Laxatives |
| lactulose | Acilac |
| Osmotic laxative Oral liquid 667mg/mL Usually 15-30mL per dose Available OTC | Acilac |
| bisacodyl | Dulcolax |
| Stimulant Laxative 5mg tabs 5mg, 10mg supps | Dulcolax |
| psylium | Metamucil, Mucillium |
| Bulk Forming Laxative | Metamucil, Mucillium, Prodiem |
| polycarbophil | Prodiem |
| sennosides | Senokot |
| Stimulant Laxative 8.6mg tabs | Senokot |
| Commonly used to treat diarrhea | Anti-diarrheals |
| loperamide | Imodium |
| 2mg tabs Available OTC | Imodium |
| diphenoxylate + atropine | Lomotil |
| 2.5mg diphenoxylate + 0.025mg atropine Narcotic | Lomotil |
| docusate sodium | Colace, Soflax |
| 100mg caps Often dosed 1-2 caps BID-QID | Colace, Soflax |
| docusate calcium | Surfak |
| 240mg caps Often dosed 1-2 caps BID-QID | Surfak |
| Commonly used to treat Nausea | Anti-nauseants |
| dimenhydrinate | Gravol |
| Tablets available OTC Injectable | Gravol |
| ondansetron | Zofran |
| 4mg, 8mg tabs & ODT Injectable Used for severe nausea in chemo patients | Zofran |
| doxylamine + pyridoxine hcl | Diclectin |
| 10mg doxylamine + 10mg pyridoxine hcl tabs Used to treat nausea and emesis in pregnancy | Diclectin |
| prochlorperazine | Stemetil |
| 5mg, 10mg tabs Injectable First gen anti-psychotic primarily used from migraines and nausea associated with chemo | Stemetil |