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Cancer and Chemo

DrugDLT/other a/eConsiderations
Cyclophosphamide DLT: Myelosuppression Acute hemorrhagic cystitis monitor liver, bladder, cbc
Carmustine DLT: delayed bone marrow suppression pulmonary fibrosis Cross BBB
Cisplatin DLT: Kidney damage ototoxic peripheral neuropathy hydrate ecg for odansetron
Methotrexate DLT: myelosuppression, pulmonary infiltrates GI ulcers pregnancy test day of admin
fluorouracil DLT: myelosuppression, oral mucositis Neuro, hand/foot syndrome highly toxic to the GI Antidote (as soon as they complain of diarrhea) : Uridine Triacetate
Mercaptopurine DLT: myelosuppression, neutro, thrombocytopenia Rare fatal liver failure reduce with allopurinol
Azacitidine CNS depression can be given for conditions that lead to cancer
Doxorubicin DLT: myelosuppression CARDIOTOXIC red urine/sweat extravasation injury watch ecg, check echo
Vincristine DLT: peripheral neuropathy assess DTR, bone marrow sparing
Paclitaxel DLT: myelosuppression severe hypersensitivity reactions premed with tylenol
Aspariginase CNS depression fatal anaphylaxis coag deficiency injury to liver, pancreas, kidney bone marrow sparing have epi ready
Tamoxifen endometrial cancer menopause s/s can be premenopause or post
Anastrozole risk of fractures msk pain osteoporosis risk menopausal s/s vit D, Ca, bisphosphonates only postmenopausul
Leuprolide tumor flare hot flash risk for sudden MI
Degarelix hot flashes decrease libido ED less muscle mass no tumor flare monitor liver and heart
Flutamide rectal bleeding Hepatoxic uses with leuprolide to reduce flare
Created by: tapolk
Popular Pharmacology sets

 

 



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