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Module 13
Section 5: Examples of drug-to-drug interactions
Question | Answer |
---|---|
Effect of taking nonsteroidal anti-inflammatory drugs (NSAIDs) with ACE inhibitors | Antagonizes effects of ACE inhibitors, resulting in increased blood pressure |
Effect of taking amiodarone with HMG-CoA reductase inhibitors, such as atorvastatin | Increased risk of rhabdomyolysis (breakdown of muscle tissue) and muscle weakness |
Effect of taking sodium polystyrene sulfonate with antacids | Binds antacid in the stomach and increases the risk of metabolic alkalosis |
Effect of taking aspirin with anticoagulants | Increased risk of bleeding due to protein displacement |
Effect of taking oral contraceptives with antibacterials | Decreased effectiveness of contraception due to increased progestin metabolism |
Effect of taking digoxin with erythromycin | Decreased renal excretion of digoxin |
Effect of taking erectile dysfunction medications with nitrates | Low blook pressure |
Effect of taking fluoroquinolone antibiotics with calcium, iron, or magnesium supplements | Decreased effectiveness of the quinolone antibiotic |
Effect of taking selective serotonin reuptake inhibitor (SSRI) antidepressants with antimigraine medications | Serotonin syndrome (condition characterized by muscle weakness, tremors, diarrhea, and confusion) |
Effect of taking iron preparations with methyldopa | Decreased absorption of methydopa |