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Pain Meds 1003

Pain and Inflammation

QuestionAnswer
What is inflammation? A response to tissue injury, it triggers a vascular response and migration of fluid and cells to injured site.
Is inflammation and infection the same thing? No, infection is caused by microorganisms and results in inflammation.
What are the two phases does the inflammation occur? Vascular Phase and Delayed Phase
What is the time frame of the vascular phase? 10-15 minutes after the injury- vasodilation, increased capillary permeability
What is the time frame for the Delayed phase? When the leukocytes infiltrate the inflamed tissue.
What are the chemical mediators? Histamine, Kinins, and Prostaglandins
What is histamine ? The first mediator in inflammatory process; it causes dilation of arteriole and increased capillary permeability.
What is Kinin? (Bradykinin) increases capillary permeability and sensation of pain
Why is Prostaglandins ? Vasodilation, relaxation of smooth muscles, increased capillary permeability, and sensitization of the nerve cells to pain
What are the cardinal signs of inflammation? Redness (Erythema), Swelling (Edema), Heat, Pain, Loss of Function
Why is Cyclooxygenase (COX)? This is the enzyme responsible for forming prostaglandins
What causes inflammation and pain at a tissue injury site? The synthesis of prostaglandins
How many forms of COX are there? Two
What is the function of COX 1? Protect the stomach lining and regulates blood platelets
What is the function of COX 2? Triggers inflammation and pain
What is the action of anti-inflammatory drugs? Inbit the biosynthesis of prostaglandin and are called, prostaglandins inhibitors OR anti-inflammatories
What other drugs are considered anti-inflammatory? analgesics(relieve pain), antipyretics(reduce elevated body temperature), and anti-coagulants (inhibit platelet aggregation)
What is the oldest anti-inflammatory drug? Aspirin
What is NSAIDs used for? To decrease inflammation and pain for clients with some type of muscloskeletal condition
What drugs are included with NSAIDs? Aspirin and other aspirin-like drugs that inhibit the enzyme COX
What is the most appropriate drug for reducing swelling, pain, and stiffness in joints? NSAIDs
If a client can take aspirin for inflammation without GI upset what drug is recommended? Salicylate
Created by: Felicitylee92
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