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bios ch. 18

TermDefinition
phase where cell not dividing or in cell cycle G0
cell cycle phases G1, S, G2, M
checkpoint where cell cycling can be checked and paused
cyclin dependent kinase only active in the presence of cyclin
M-cyclin necessary to activate CdK
CdK inhibitors no cycling even if cyclin-CdK -p
what starts cell cycling growth factors
Rb is a tumor supressor
p21 inhibits S-cyclin-CdK
p53 tumor supressor
M-cyclin/CdK triggers changes in prophase
prophase chromatin condenses and nuclear envelope is broken
cohesions keeps sister chromatids together
when all kinetochores are bound to MTs and pulled equally: anaphase promoting complex/C becomes active
anaphase promoting complex/C (APC/C) is a ubiquitin ligase
dyneins pull MTOC towards (chromosomes or plasma membrane)
kinesins push MTOC away (MTOCs separate)
cytokinesis split one cell into 2
anaphase chromosome separation
APC/C ubiquinates M-cyclin and securin
once ubiquinated, separase cleaves cohesion
Created by: lutmanlucy21
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