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Stack #37897
Pharm 1
| 1 | 2 | 3 | 4 | 5 | 6 | 7 |
|---|---|---|---|---|---|---|
| carbamazepine | block Na | DOC. partial seizures | DOC: trigeminal neuralgia | treat Bipolar | Diplopia, Ataxia | Mild leukopenia |
| carbamazepine | Hyponatremia | Water intoxication(SAIDS) | aplastic anemia/agranulocytosis | dec. Ethosuximide valporate, estrogen (EVE) | Valporate, Erthromycin Inc. toxicity | (blank) |
| Phenobarbital | Enhance GABA | use in Tonic clonic/partial seizure | Induce liver microsomal enzyme: Neonatal Hyperbilirubinemia | Allergic rxn. | Porphyria | (blank) |
| Phenobarbital | Fetal malformation | dec. valporate, estrogen | stevens johnson syndrom , Blood dyscrasias | (blank) | (blank) | (blank) |
| Sodium Valporate | Blocks Na+ | Blocks T-Ca channels | Inc. GABA | Very effective in Absence seizures | DOC Myoclonic seizures | use in Bipolar depression |
| Sodium Valporate | Migraine prophylaxis | Tremor | weight gain, Hair loss, menstrual disturbances | Idiosyncratic hepatoxicity in <2year old | blocks folic acid ->Spinal bifida | (blank) |
| Lamotrigine | Block Na+ | Epilepsy/Skin Rash | Not for <16 yrs | Inc. risk of Dermatitis | (blank) | (blank) |
| Ethosuximide | Absence Seizures Only | Block T-type Ca++ channels | HL 40 hrs | Neutropenia | (blank) | (blank) |
| GABAPENTIN | use for Neuropathic pain | not metabolized in liver, no induction | similar to TIAGABINE | TOPIRAMATE | LEVETIRAC ETAM | binds voltage-gated Ca++ channels |
| ACETAZOLAMIDE | carbonic anhydrase inh. | antiseizure for menstrual associate seizure | (blank) | (blank) | (blank) | (blank) |
| Clonazepam | Useful in myoclonic seizures | Use: Absence seizures | (blank) | (blank) | (blank) | (blank) |
| Benzodiazepines | Terminate status epilepticus | for general convulsion | Tolorence and paradoxical excitation | for Febrile convulsion | (blank) | (blank) |
| Phenytoin | Block Na | zero order kinetics, induce liver enzyme | DOC: Generalize tonic clonic | Cerebellar effects | Gingival hyperplasia | Hirsuism, RASH |
| Naproxen | Long HL Nsaids | PIROXICAM | (blank) | (blank) | (blank) | (blank) |
| Ketorolac | Better analgesic | Only Nsaid given Parenterally | Treat Post opperative pain | (blank) | (blank) | (blank) |
| Mefenamic Acid | good in Dysmenorrhea | (blank) | (blank) | (blank) | (blank) | (blank) |
| Indomethacin | Good anti inflammatory | NSaid that inhibit Phospolipase A2 thus leukotrienes | inhibite T and B lymphocyte proliferation | depression, headace | renal dysfunction in neonates | For closing PDA |
| Indomethacin | Not used as analgesic b/c of toxicity | use for gout, Anky-spon, Arthritis | (blank) | (blank) | (blank) | (blank) |
| Mesalamine | for ulcerative colitis | (blank) | (blank) | (blank) | (blank) | (blank) |
| Celecoxib | Do not give to sulfa allergic pts. | (blank) | (blank) | (blank) | (blank) | (blank) |
| Acetaminophen | suicide drug | hepatotoxic.. | day 4: elevated liver enzymes, jaundice, encephalopathy | Day 1: N/V | Renal toxic (oliguria) | dec. Glutathione thus inc. NAPQ1 |
| Acetaminophen | CI: in Alcohol, HIV | treat with N-acetyl cysteine | Treat OsteoArtritis | (blank) | (blank) | (blank) |
| Methotrexate | anti-metabolite | inhibits Cytokine production | inhibits purine biosynthesis | takes 2-3 wks. | Lung fibrosis | triad: renal/hepatotoxic/thrombocytopenia |
| Methotrexate | cause Folic acid Deficiency->teratogenic | (blank) | (blank) | (blank) | (blank) | (blank) |
| Gold salts | aurothiomalate | long t 1/2 of 22 days. takes 3 mths. for steady state | inhibits phagocytes and T cell | dec. Lyzosomal enzyme activity | dec. histamine release | cause: Dermertitis somatitis gastritis vaginitis. |
| Gold salts | triad: hepatic / renal /thrombo,agranulocytosis | do not give with penicillamine, antimalarials, immunosuppressant | (blank) | (blank) | (blank) | (blank) |
| Hydroxychloroquine | inhibits mitogen-induced proliferation of lymphocytes | dec. leukocytes chemotaxis | dec. Lyzosomal enzyme | dec. IL-1 formation | dec. free radicals | inhibits Phospolipase A2 |
| Hydroxychloroquine | cause Dermatitis | Blindness | do not use in Psoriatic arthritis | (blank) | (blank) | (blank) |
| Sulfalsalzine | dec. prostaglandins (salicylate) | RA drug | (blank) | (blank) | (blank) | (blank) |
| Leflunomide | inh. autoimmune T cell proliferation | inh. production of autoantibodies by B lymphocytes | decrease de novo RNA synthesis -> common in Lymphocyte | hepatotoxic | like Azathioprine inhibits both T and B cell function | As effective as methotrexate, but safer |
| Infliximab | Binds TNF-alpha and prevents it | Infusion rxn. urticaria-> fever-> hypotension | cause respiratory tract infection | (blank) | (blank) | (blank) |
| Etanercept | Bind TNF molecules | injection site rxn: erythema... also serious infection | (blank) | (blank) | (blank) | (blank) |
| Adalimumab | Human IgGI antibody to TNF | all anti TNF are SC | (blank) | (blank) | (blank) | (blank) |
| AnAkinrA | IL-1 receptor antagonis | (blank) | (blank) | (blank) | (blank) | (blank) |
| Indomethacin | Nsaids | prevent acute attack in gout | (blank) | (blank) | (blank) | (blank) |
| Colchine | dec. glocoprotein production in leukocytes | prevent acute attack in gout | Abdominal pain N/V | bloody diarrhea...Mitosis inh. | Prophylactic in Gout | (blank) |
| Probencid | Sulfinpyrazone->peptic ulcer | Uricosuric drug by prevention of reabsorption | PROlong penicillin, Indomethacine, Methotrexate, Sulfonylureas | Potasium citrate (good for urine) | do not take with aspirin, use acetaminophen | (blank) |
| Meperidine | difuse rapidly across placenter, not associated with uterine rxn. | Not as much respiratory depression | drug interaction with MAO inhibitors | do not use with other opioid b/c Hyperpyrexic coma | (blank) | (blank) |
| Fentanyl | Remifentanil | used in painful procedures | transdermally for chronic pain | Rapid metabolism | Teratogenic | (blank) |
| Methadone | Long Half life than morphine | suitable drug to rotate with morphine | long time to develop tolerance | withdrawal syndrome is mild | treat morphine addicts | (blank) |
| Codeine | use with aspirin or acetaminophen | use for Cough | (blank) | (blank) | (blank) | (blank) |
| Pentazocine | high incience of dysphoria | Less dependence, emetic and constipating effects | (blank) | (blank) | (blank) | (blank) |
| Tramadol | central acting analgesic | inc. 5HT neurotransmission | block by ondansetron | (blank) | (blank) | (blank) |
| Clonidine | alpha 2 receptor agonist | effective analgesic against acute and chronic pain | (blank) | (blank) | (blank) | (blank) |
| Amitriptyline | block NE reuptake | (blank) | (blank) | (blank) | (blank) | (blank) |
| Alendronate | biphosphonates | cause esophagitis | Risedronate | Prophylaxis for osteoporosis | promote osteoclast apoptosis | treatment for hypercalcemia (IV pamidronate) |
| Teriparatide | PTH analog | intermittent injection stimulate bone formation | (blank) | (blank) | (blank) | (blank) |
| Calciferol | vit D | hypercalcemia serum Ca++ > 10.5mg/dL | increase serum ca++ and phosphate | polydipsia polyuria | CNS depression leading to COMA | treat with loop diuretic to block Ca++ reabsorption |
| Plicamycin | IV lowers serum calcium within 24 hrs. | not DOC for hypercalcemia b/c toxicity | Triad toxicity | (blank) | (blank) | (blank) |
| Calcium gluconate | IV for acute hypocalcemic tetany | use in cardiac dyshythmias caused by hyperkalemia | (blank) | (blank) | (blank) | (blank) |
| Salcatonin | calcitonin | treat hypercalcemia associated with Malignancy (MEN) | treat paget's disease | treat postmenopausal + coticosteroid-induced osteoporosis | Same use as bisphosphonates | (blank) |
| Succinylcholine | depolarization | cause Muscle fasciculation-> myoglobinuria | post operative pain, not effective in Myasthenic gravis | cause Hyperkalemia..CI in burns | cause cardiac arrhythmias(spinal cord injury) | Malignant hyperthermia can be triggered |
| Succinylcholine/d-Tubocurarine | inc. toxicity: Inhalational anesthetics | Aminoglycoside inc. toxicity | (blank) | (blank) | (blank) | (blank) |
| d-Tubocurarine | competitive nicotinic antagonist | others: AtraCURIUM fro people with atypical cholinesterase | Na+ cannot flow in and depolarize membrane | Head->Neck->respiratory | induce histamine release->hypotension, bronchospasms | (blank) |
| d-Tubocurarine | block muscuranic->tachycardia | block autonomic ganglia->Hypotension | (blank) | (blank) | (blank) | (blank) |
| Mivacurium/Rapacuronium | Non-deoplrising blocker | shot and rapid acting | neglible histamin release | (blank) | (blank) | (blank) |
| Baclofen | Gaba B analog | DOC: spinal spasticity | DOC: Multiple Sclerosis Spasticity | cause seizures | usage: benzodiazepines(GABA-A) alternative | (blank) |
| Botulinum toxin | use for Dystonias | diplopia->dysphagia->dysarthria | (blank) | (blank) | (blank) | (blank) |
| Danatrolene | acts on the ryanodine receptor to block Ca+ | Treat malignant hyperthermia (IV) | (blank) | (blank) | (blank) | (blank) |
| Bupivacaine | epidural anesthesia (Labor) | cause arrhythmias | (blank) | (blank) | (blank) | (blank) |
| Prilocaine | Methemoglobin in neonate | Vasoconstrictor activity | use in Dental procedures | (blank) | (blank) | (blank) |
| Cocaine | esters LA | ->PABA->antagonize sulfornamides | asthma | allergic dermatitis | use in Ophthalmic | has intrinsic vasoconstrictor activity |
| halothane | hypotension -> inc. cerebral blood flow | inc. sensitivity of heart to Epi, NE | myocardial depression | hepatitis/hyperthermia | Difusion hypoxia/bone marrow depression | spontaneous abortion with chronic exposure |
| Isoflurane | Respiratory irritant/sympathetic stimulation | CO is maintained | (blank) | (blank) | (blank) | (blank) |
| Desflurane | Fast acting halogen | Respiratory irritant/sympathetic stimulation | CO is maintained | (blank) | (blank) | (blank) |
| Sevoflurane | cause SEizure but not Tachycardia | Fast acting halogen | (blank) | (blank) | (blank) | (blank) |
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kar556@hotmail.com
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