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1.10
Drugs
| Term | Definition |
|---|---|
| Femotidine | H2RA |
| Docusate | anion su |
| furosemide(Lasix) | loop diuretic |
| bumetanide (Bumex) | loop diuretic |
| "pril"s | ACEI |
| methyldopa (aldomet) | hypertension for preg women |
| met | thiazide diuretic |
| "sartan"s | ARBs |
| "lol"s | Beta Blocker |
| Sacubitril/valsartan (Entresto) | ARNI |
| Spironolactone (Aldactone) | Aldosterone Antagonists |
| Eplerenone (Inspra) | Aldosterone Antagonist |
| Torsemide (Demadex) | Loop Diuretic |
| Digoxin (Lanoxin, Digitek) | inhibits Na+/K+ ATPase decreases Na and Ca export and SNS outflow (NE) increases cytosolic Calcium (increases contractility, increase CO) Last tool in toolbox-easy to overdose |
| dDigibind | anti-digoxin immunotherapy used for digoxin overdose |
| Dobutamine (Dobutrex) | short term relief of HF-emergency setting B1/B2 agonist |
| Milrinone (Primacor) | short term relief of HF-emergency setting inhibitor of PDE3 (prevents breakdown of cAMP) |
| Beta Blockers dont work well with: | Variant Angina |
| Isosorbide dinitrate (Isordil) | Organic Nitrate |
| Isosorbide mononitrate (Imdur) | Organic Nitate |
| Nitroglycerin (NitroBid) | Organic Nitrate |
| Drug classes for Angina | Organic Nitrate Calcium Channel Blockers Beta Blockers |
| Nifedipine (Procardia, Adalat) | heart specific (DHPs) Calcium Channel Blocker |
| Amlodipine (Norvasc) | heart specific (DHPs) Calcium Channel Blocker |
| Diltiazem (Cardizem) | Non-DHPs Calcium Channel Blocker and calcium channel blocker used for Class 4 antiarrhythmia drug and benzothiazepines (Calcium channel blockers) antihypertensive drug (HEART) |
| Verapamil (Calan) | Non-DHPs Calcium Channel Blocker and calcium channel blocker used for Class 4 antiarrhythmia drug and phenylalkylamines (Calcium channel blockers) antihypertensive drug (HEART) |
| 1st line therapies for stable angina | Calcium channel blockers Beta Blockers |
| "Statin"s | HMG-CoA reductase inhibitors |
| Drug interaction with HMG-CoA reductase Inhibitors | Gemfibrozil (increased risk of rhabdomyolysis) |
| Ezetimibe (Zetia) | inhibits intestinal absorption of cholesterol NPC1- Niemann-Pick type C disease-like protein |
| Drug interactions with Ezetimibe | Bile Acid sequestrants |
| cholestyramine (Questran) | Bile Acid Sequestrants (BAS) |
| Drug Interactions of Bile Acid Sequestrants | Inhibits absorption of many drugs Digoxin, propanolol (have to take drugs 1 hour before or 4 hours after taking BAS) |
| Niacin (nicotinic acid) | best drug to increase HDL |
| "FIBRates" | PPARa activators |
| what could PPARa activators cause | teratogenic (birth defects) |
| Evolocumab (Repatha) | PCSK9 Inhibitor |
| Alirocumab (Praluent) | PCSK9 Inhibitor |
| what drug class works well with PCSK9 Inhibitors? | STATINS |
| Dysopyramide (Norpace) | Class 1A sodium channel blockers |
| Procainamide (Pronestyl) | Class 1A sodium channel blockers |
| Lidocaine (Xylocaine) | Class 1B sodium channel blockers |
| Mexilitine (Mexitil) | Class 1B sodium channel blockers |
| Flecainide (Tambocor) | Class 1C sodium channel blockers |
| Propafenone (Rhythmol) | Class 1C sodium channel blockers |
| Esmolol (Brevibloc) metoprolol (lopressor) | nonselective BB used for Class 2 antiarrhythmia drug esmolol --> short half life |
| Carvedilol (Coreg) Propanolol (Inderal) | Selective BB used for Class 2 antiarrhythmia drug |
| Amiodarone (cordarone) | Potassium channel blocker used for Class 3 antiarrhythmia drug broad spectrum AAD (4 classes-1,2,3,4) most commonly prescribed |
| Dofetilide (Tikosyn) | highly selective Potassium channel blocker used for Class 2 antiarrhythmia drug narrow spectrum AAD: atrial fibrillation |
| Sotalol (Betapace) | potassium channel blocker used for Class 3 antiarrhythmia drug also a strong beta blocker |
| Adenosine | AADs increases K+ conductance hyperpolarizes the membrane prolongs refractory period and slows conduction velocity in AV nodes indicates for supraventricular arrhythmias |
| which classes are considered pro-arrhythmic? | Class 1 (a/c) and 3 |
| which class of AADs are least cardiotoxic | Class 1B: lidocaine |
| "dipine"s | Dihydropyridines (Calcium channel blockers) antihypertensive drug vascular smooth muscle |
| "azosin"s | Alpha-1 adrenergic Antagonists antihypertensive drug |
| Reserpine (serpasil) | Peripheral Adrenergic antagonist affects storage of NE in vesicles antihypertensive drug |
| Clonidine (Catapress) | Centrally acting agents alpha 2 adrenergic receptor agonists |
| Guanabenz | Centrally acting agents alpha 2 adrenergic receptor agonists |
| Guanafacine | Centrally acting agents alpha 2 adrenergic receptor agonists |
| Aliskiren (Tekturna) | Renin Inhibitors |
| Hydralazine (Aprasoline) | Vasodilators |
| Minoxidil (Loniten) **know brand name | Vasodilators |
| Sodium Nitroprusside (Nitropress) | Vasodilators |
| "entan"s | endothelin Receptor Antagonists (blocks A and B) treats pulmonary hypertension |
| "afil"s (Revatio and Adcirca) | Phosphodiesterase inhibitors treats pulmonary hypertension prolongs vasodilate effect of NO |
| "prost"s | Prostacyclins (increases vasodilation) treats pulmonary hypertension |
| Riociguat (Adempas) | Guanylate cyclase stimulator treats pulmonary hypertension increase NO to relax pulmonary arteries |
| Sildenafil | Viagra |
| Vardenafil | Levitra |
| Tadalafil | Cialis |
| Avanafil | Stendra |
| Sildenafil (Viagara) main ADR | Visual Disturbance |
| Vardenafil (Levitra) main ADR | Nasal Congestion |
| Tadalafil (Cialis) main ADR | Back pain, Myalgias |
| Avanafil (Stendra) | Back pain |
| Sildenafil (Viagra) is also indicated for | Pulmonary Hypertension |
| Tadalafil (Cialis) is also indicated for | Pulmonary Hypertension Benign prostate hypertrophy |
| Alprostadil | MUSE pallet Caverject |
| MUSE pallet route | intraurethral insertion |
| Caverject | intracavernosal injection |
Created by:
megangodfrey97
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