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chap 12

QuestionAnswer
pharmacogenomics a field of study that defines the hereditary basic of individual differences in absorption, distribution, metabolism, and excretion (the ADME processes)
adverse drug reaction(ADR) an unintended side effect of a medication that is negative or in some way injurious to a patients health
Anaphylactic shock a potentially fatal hypersensitivity reaction producing severe respiratory distress and cardiovascular collapse
drug resistance the reduction of effectiveness in a drug such as an antibiotic or antineoplastic
idiosyncrasy an unexpected reaction the first time a drug is taken, generally due to genetic causes
acute viral hepatitis an inflammatory condition of the liver caused by viruses
cirrhosis a chronic liver disease causing loss of function
hyperthyroidism a condition in which thyroid hormone secretions are above normal, often referred to as an overactive thyroid
obstructive jaundice an obstruction of the bile duct that causes hepatic waste products and bile to accumulate in the liver
complexation when two different molecules associate or attach to eachother
displacement a drug that is bound to a plasma protein is removed when another drug of greater binding potential binds to the same protein
enzyme induction the increase in hepatic enzyme activity that results in greater metabolism of drug
enzyme inhibition the decrease in hepatic enzyme activity that results in reduced metabolism of drugs
additive effects the increased effect of two drugs with similar pharmacological actions
antidote a drug that antagonizes the toxic effect of another
circadian rhythm body's biological process that repeats in a 24 hour cyclical pattern
potentiation when one drug with no inherent activity of its own increases the activity and effect of another drug
synergism when two drugs with similar pharmacological actions produce greater effects than the sum of individual effects
drug diet interactions when elements of ingested nutrients interact with a drug and this affects the disposition of the drug
Created by: laylaoxendine
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