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chap 12
| Question | Answer |
|---|---|
| pharmacogenomics | a field of study that defines the hereditary basic of individual differences in absorption, distribution, metabolism, and excretion (the ADME processes) |
| adverse drug reaction(ADR) | an unintended side effect of a medication that is negative or in some way injurious to a patients health |
| Anaphylactic shock | a potentially fatal hypersensitivity reaction producing severe respiratory distress and cardiovascular collapse |
| drug resistance | the reduction of effectiveness in a drug such as an antibiotic or antineoplastic |
| idiosyncrasy | an unexpected reaction the first time a drug is taken, generally due to genetic causes |
| acute viral hepatitis | an inflammatory condition of the liver caused by viruses |
| cirrhosis | a chronic liver disease causing loss of function |
| hyperthyroidism | a condition in which thyroid hormone secretions are above normal, often referred to as an overactive thyroid |
| obstructive jaundice | an obstruction of the bile duct that causes hepatic waste products and bile to accumulate in the liver |
| complexation | when two different molecules associate or attach to eachother |
| displacement | a drug that is bound to a plasma protein is removed when another drug of greater binding potential binds to the same protein |
| enzyme induction | the increase in hepatic enzyme activity that results in greater metabolism of drug |
| enzyme inhibition | the decrease in hepatic enzyme activity that results in reduced metabolism of drugs |
| additive effects | the increased effect of two drugs with similar pharmacological actions |
| antidote | a drug that antagonizes the toxic effect of another |
| circadian rhythm | body's biological process that repeats in a 24 hour cyclical pattern |
| potentiation | when one drug with no inherent activity of its own increases the activity and effect of another drug |
| synergism | when two drugs with similar pharmacological actions produce greater effects than the sum of individual effects |
| drug diet interactions | when elements of ingested nutrients interact with a drug and this affects the disposition of the drug |
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laylaoxendine
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