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1.6 Exam
SEROTONIN
| Question | Answer |
|---|---|
| 5HT3 | Stimulates Pain Nerves, Regulates Vomiting |
| 5HT4 | Stimulates GI Tract |
| What is the Role of 5-HT3R | Stimulate Nausea Vomiting and detect abdominal pain |
| Acetylcholine is associated with the PNS or SNS | PNS |
| 5HT4R PROMOTES OR INHIBITS BILE MOVEMENTS | PROMOTES BILE MOVEMENTS |
| What is the Emetic Pathway associated with? | Vomiting |
| What are 5-HT3R Antagonists | Setrons |
| 5-HT3R ANTAGONIST DRUGS | ONDANSETRON = ZOFRAN GRANISETRON = KYTRILL DOLASETRON = ANZMET PALONOSETRON = ALOXI |
| What treats IBS -C | TEGASEROD (ZELNORM) |
| What drug treatment is used for IBS-D | ALOSETRON (LOTRONEX) |
| What drug treatment is used for IBS-D But has LESS CVS Issues? | Prucalopride (Motegrity) |
| Activity of the Trigeminal nerve is regulated by which brainstem? | 5-HT |
| Which class of Serotonergic drugs are used to treat Migraine Headaches? | Triptans |
| Which Triptans have the Longest half-lives, the slowest onset of action, and less headache recurrence | FROVA & NARA |
| What are the MOA for Triptans | Agonist of 5-HT1B/1D, |
| What are Drug Interactions with Triptans | Ergot-containing drugs, MAO Inhibitors, SSRIs |
| What causes Serotonin Syndrome | Over activation of central 5-ht Receptors |
| What are Emetic Pathways are associated with? | Vomiting |
| What drugs may cause Serotonin Syndrome | SSRIs, TCA, E.g.s Merperidine, Dextromethorphan, Tramadol; MAOIs; Amphetamines, Ephedrine; Tryptophan, Triptans, Tegaserod, Ergotmaine, Buspirone, LSD |
| What does Ergot Alkaloids & Postpartum Atony Treat? | Prevention and treatment of postpartum atony and hemorrhage |
| What are Ergot Alkoids and Postpartum Atony drugs? | Ergonovine (ERGOTRATE) Methylergonovine (Methergine) |
| What drugs are used to treat Aborting (Acute) Migraines associated with 5-HT1F Receptor Agonists | Ditans |
| What are Migraine Prophylaxis 1st Line Beta Blocker Therapy drugs? | Propranolol (INDERAL), TIMOLOL (BLOCADREN) |
| What are Migraine Prophylaxis 1st Line Antiepileptic drug therapies? | Valproic acid (DEPAKENE), Topiramate (TOPAMAX), Divalproex (DEPAKOTE) |
| What are Migraine Prophylaxis 1st Line Tricyclic antidepressants drug therapies? | Amitriptyline (ELAVIL) |
| What are Migraine Prophylaxis Alternative channel blockers drug therapies? | Verapamil (CALAN)= CALCIUM CHANNEL BLOCKER; BOTOX, MYOBLOC |
| What are Migraine Prophylaxis New Drug Therapies? | Erenumab (Aimovig), Eptinezumab (VYEPTI), Fremanezumab (AVOJY), Galcanezumab (EMGALITY) |
| What is the Migraine Prophylaxis herbal preparation for drug therapy? | Feverfew |
| Access of acetylcholinesterase inhibitors leads too Much Acetylcholine causing what type of crisis? | Cholinergic Crisis |
| Antibodies block nerve terminals in neuromuscular junction b/c of Autoimmune disorder causes what kind of Crisis? | Myasthenic Crisis |
| What Crisis presents Muscle weakness and potential respiratory failure? | Cholinergic Crisis and Myasthenic Crisis. |
| What is used to diagnosis Cholinergic and Myasthenic Crisis | Edrophonium |
| Degeneration of Nigrostriatal pathway results in reduced DA levels and hyperactivity of cholinergic nerves and EXCESSIVE RELEASE of GABA, Results in which Disease? | Parkinson's Disease ; (Normal skeletal muscle require s balanced Release of GABA) |
| What happens when Ach is released from cholinergic nerves? | GABA is Increased! |
| What happens when DA nerves inhibit Ach release? | GABA is decreased |
Created by:
mcain970
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