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Blood Disorders

Clopidogrel Plavix Anti-platelet Medicine Increased risks of bleeding For blood clot prevention - interferes with platelet aggregation Use prophylactically in patients with previous coronary/vascular events TIA
Triclopidine Ticlid Anti-platelet medication Increased risk of bleeding For blood clot prevention - interferes with platelet aggregation Use prophylactically in patients with previous coronary/vascular events TIA
NSAIDs Ibuprofen Used in blood clot prevention treatment Risk of bleeding
Abciximab Reopro IV - glycoprotein 2b / 3A receptor antagonist Anti-platelet medication IV; blood clot prevention Risk of bleeding
Eptifibatdie Integrilin IV - glycoprotein 2b / 3A receptor antagonist Anti-platelet medication IV; blood clot prevention Risk of bleeding
Tirofiban Aggrastat IV - glycoprotein 2b / 3A receptor antagonist Anti-platelet medication IV; blood clot prevention Risk of bleeding
Dipyridamole and ASA Aggrenox Prevents recurrent strokes Anti-platelet combination medication Risk of bleeding
Aspirin ASA Irreversibly binds to platelets Anti-platelet medication low dose 81 mg
Heparin Anticoagulants; stops or slows down clotting process IV or SC Doesn't dissolve clot itself dash bodies natural process does Inhibits Factor XA and II (thrombin) & accelerates effects of anti-thrombin III Antidote - Protamine Sulfate IV Side effects - bleeding and thrombocytopenia (decreased platelet count) Requires direct patient monitoring with partial thromboplastin time PTT
LMWH - low molecular weight heparin Anticoagulant medication - stops or slows down clotting process - SC No frequent dosing needed - once to twice a day No lab testing required Binds to antithrombin III to inactivate factor XA which prevents clot formation Similar effects and bleeding rates as heparin If patient gets thrombocytopenia from heparin they can with lmwh -Give direct thrombin inhibitor instead
Enoxaparin Lovenox LMWH - SC
Dalteparin Fragmin LMWH SC
Tinzaparin Innohep LMWH SC
Lepirudin Argatroban Direct Thrombin Inhibitor IV -
Fondaparinux Arixtra Factor Xa Inhibitor - SC Treatment and blood clot prevention Used in patients with Heparin induced thrombocytopenia HIT
Warfarin Coumadin Prevents activation of clotting factors that require vitamin K Factors II, VII, IX and X Many drug and food interactions - antibiotics and aspirin; Vit K Reverse effect - vitamin K Oral - Myphyton Injection - Aqua-Myphyton
Mephyton Reverses effect of warfarin PO, tablet Vitamin K
Aqua-Mephyton Reverses effect of warfarin Injection Vit K
DOACs - Direct oral anticoagulants Treats Non-valvular atrial fibrillation AFib Peripheral artery disease PAD Venous thromboembolism VTE, DVT Main advantage doesn't require routine lab monitoring Severe bleeding can be treated with IV clotting factors
Dabigatran Pradaxa DOAC Reversed by Idarucizumab - Praxbind
Apixaband Eliquis DOAC
Betrixaband BevyxXa DOAC
Rivaroxaban Xarelto DOAC Reversed by: Andexanet Alfa - Andexxa
Edoxaban Savaysa DOAC No reversals approved
Thrombolytic Agents Used to dissolve newly formed clots, such as from mi or stroke Interacts with anticoagulants, anti-platelet drugs, and NSAIDs - increases the risk of bleeding Thrombolytics tPAs - tissue plasminogen activators
Streptokinase Streptase Thrombolytic
Urokinase Abbokinase Thrombolytic
Altaplase Activase tPA
Reteplase Retavase tPA
Tenecteplase TNkinase tPA
Iron Therapy for microcytic anemia 100-200mg Fe/day in divided doses for 6m Different forms have different absorption rates and tolerability Side effects - constipation, diarrhea, dark stools, nausea, GI pain Iron and large amounts is toxic Interactions Antacids, coffee, tea, and milk - decreases absorption Interferes with tetracycline and others' absorption Give between meals; at least 2 hours before antacid Increase absorption with vitamin C
Ferrous Sulfate Iron Therapy PO microcytic anemia
Ferrous Gluconate Iron Therapy PO microcytic anemia
Ferrous Fumarate Iron Therapy PO microcytic anemia
Polysaccharide Iron Complexes Iron Therapy PO microcytic anemia
InFeD Iron Therapy IV microcytic anemia
Dex-Ferrum Iron Therapy IV microcytic anemia
Sodium Ferric Gluconate Complex Ferrlecit Iron Therapy microcytic anemia
Iron Sucrose Venofer Iron Therapy Used in hemodialysis, microcytic anemia
Macrocitic anemia Deficiency and vitamin B12 and or folic acid, in Paris DNA synthesis causing abnormal maturation of red blood cells causing large cells Treatment Vitamin B12 intrinsic factor needs to be present for absorption Folic acid -rx 1 mg tablet, OTC.4 mg or 0.8 mg tablet
Epoetin Alfa Epogen Procrit Chronic anemia and kidney disease treatment with erythropoiesis to stimulate red blood cell production Side effects hypertension, thrombosis
Darbepoetin Alfa Aranesp Chronic anemia and kidney disease treatment with erythropoietin to stimulate red blood cell production Side effects hypertension, thrombosis
Sickle cell anemia Treatment pain management, chemotherapy, antibiotics, folic acid 1 mg per day needed Analgesics - NSAIDs, acetaminophen, opioids Extremely painful genetic disease
Hydroxyurea Hydra Droxia Decreases frequency of sickle cell crisis Decreases sickling of red blood cells and increases fetal hemoglobin production Side effects bone marrow suppression - patients more prone to infection All immunizations need to be up to date Sometimes treated prophylactically with antibiotics
Aminocaproic Acid Amicar Hemophilia Encourages coagulation after surgery
Tranexamic Acid Cyklokapron Hemophilia Used short-term for tooth extractions
Factor VIII Hemophilia A - classic Plasma derived or recombinant
Factor IX Hemophilia B- Christmas Disease Plasma derived or recombinant
Created by: Adriannld
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