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HIV Pharm

NameClassMOASide EffectsNotes
Maraviroc CCR5 Antagonist
Enfuvirtide Fusion Inhibitor
Fuzeon Fusion Inhibitor
Lamivudine (3TC) NRTI
Emtricitibine (FTC) NRTI
Abacavir NRTI - must screen for HLA-B*5701 - only NRTI without Hep B activity
Tenofivir Disoproxol Fumarate (TDF) NRTI - Fanconi's Syndrome: renal tubular dysfunction, phosphaturia, and glucosuria - headache - nausea - vomiting - diarrhea - rare lactic acidosis - bone demineralization
Tenofivir Alafenamide (TAF) NRTI - less nephrotoxic - raises LDL cholesterol - weight gain
Efavirenz NNRTI - crosses BBB - nightmares/vivid dreams that lessen over time - K103N Mutation confers resistance to three drugs in class - Atripla: Efavirenz, Emtricitaine, and Tenofovir
Rilpivirine NNRTI - Complera: Truvada + Rilpivirine
Atazanavir Protease Inhibitor - Insulin Resistance - Hyperglycemia - Diabetes - Dyslipidemia (increases HDL) - Asymptomatic hyperbilirubinemia (indirect bili) - Fat Redistribution - Accumulative Exposure increased risk of myocardial infarction - PR longation - nephrolithiasis
Darunavir Protease Inhibitor - blocks cellular proteases - CYP450 interactions - Insulin Resistance - Hyperglycemia - Diabetes - Dyslipidemia - Fat Redistribution - Accumulative Exposure increased risk of myocardial infarction
Indinavir Protease Inhibitor - kidney effects - nephrolithiasis to sterile pyuria: drug deposits, need to drink 2-3 L H2O/day, must take on empty stomach
Raltegravir Integrase Inhibitor - targets HIV-1 integrase - backbone agent in ART - disadvantage is bid dosing
Dolutegravir Integrase Inhibitor - different resistance pattern than Raltegravir - Triumeq: Dolutegravir + 3TC/Abacavir may be superior to Atripla
Elvitegravir Integrase Inhibitor - found in quad pill - combine with Cobicistat to allow for 1/day dosing
Bictegravir Integrase Inhibitor
Ritonavir Pharmacokinetic (PK) Booster - pharmokinetic booster - RTV Boost: blocks clearance of second protease inhibitor
Cobicistat Pharmacokinetic (PK) Booster - no activity against HIV - potent CP3A inhibitor - pharmocokinetic enhancer of Elvitegravir: allows for 1/day dosing
Created by: vwang0101
Popular Pharmacology sets

 

 



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