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Aging Midterm

QuestionAnswer
What is senescence? A deteriorative change that causes increased mortality
What is hormesis? stimulatory effects of low doses of substances known to be toxic at higher doses
What do adaptive theories of the evolution of aging say? propose that senescence leading to death provides a selective advantage to the species
What do non-adaptive theories of the evolution of aging say? propose that senescence is detrimental to fitness and is outside the force of natural selection
What is antagonistic pleiotropy? when a gene is beneficial to the organism's fitness early on in life and is detrimental to the organism's fitness later on due to a decline in the force of natural selection
“Rate of living” Pearl 1928, Rubner 1908, Weismann 1889. Life span inversely proportional to metabolic rate. Many exceptions (e.g., bats, humming birds),
Somatic mutation theory (Szilard 1959). DO NOT CONFUSE WITH “MUTATION ACCUMULATION” EVOLUTIONARY THEORY! Genetic mutations accumulate with time leading to functional failure.
What is the Hayflick limit? the limited number of cell divisions that human fibroblasts and other cell types will undergo in cultur
What are the products of glycolysis? pyruvate, NADH, ATP
Where do the products of glycolysis go and why? the mitochondria to support the Krebs cycle and oxidative phosphorylation/ETC
What does the Krebs cycle produce? reducing equivalents and building blocks for macromolecules
What does the ETC do? reduce oxygen and use the energy to convert ADP to ATP
be able to draw ATP! ok.
Created by: javaughnr
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