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Analgesic/Anasthesia
Pharmacology
| Question | Answer |
|---|---|
| What is an Analgesic? What are the two basic categories? | Medications used to reduce or eliminate pain without LOC or loss of sensation. Two basic categories are opioids and nonopioids. |
| What are Prostaglandins? | Chemicals released after tissue damage leading to pain, inflammation, platelet aggregation and creates pain sensation. |
| What is Substance P? | A neurotransmitter within the spinal cord involved in the neural transmission of pain. It controls whether pain signals will continue to the brain. |
| What is Cyclooxygenase (COX)? | Enzyme involved in the formation of prostaglandins. |
| When tissue is damaged, chemical mediators are released. Name them. | Hydrogen Ions, Histamine, Bradykinin, Prostaglandins, Potassium Ions (**Help! His Brain Processed Pain!) |
| T or F. Aspirin inhibits both COX1 and COX2? | TRUE |
| What category of drugs fall under nonopioid analgesics? | NSAIDs, Acetaminophen |
| Define Nociceptor. | Refers to activation of receptor nerve endings that receive and transmit pain signals to the spinal cord and brain. (Injury to tissues produces nociceptor pain). |
| Define Neuropathic Pain. | Pain caused by direct injury to the nerves and typically is described as burning, shooting, or numb pain. (Responds less successfully to drugs) |
| What happens when nociceptors are stimulated? | The process of pain transmission begins. |
| A FIbers are characterized as being... | covered (myelinated), signal sharp well-defined pain, fast |
| C Fibers are characterized as being... | unmyelinated, conduct dull, poorly localized pain, slow |
| Two types of sensory neurons that signal pain to spinal cord? | A and C Fibers |
| NSAIDs work at the _________level, whereas Opioids (Narcotics) act within the _____________. | Peripheral, CNS |
| These are used to treat moderate to severe pain levels: | Opioids. Moderate efficacy: Codeine and Hydrocodone. High efficacy for severe pain: Morphine and meperidine (Demerol). |