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Analgesic/Anasthesia

Pharmacology

QuestionAnswer
What is an Analgesic? What are the two basic categories? Medications used to reduce or eliminate pain without LOC or loss of sensation. Two basic categories are opioids and nonopioids.
What are Prostaglandins? Chemicals released after tissue damage leading to pain, inflammation, platelet aggregation and creates pain sensation.
What is Substance P? A neurotransmitter within the spinal cord involved in the neural transmission of pain. It controls whether pain signals will continue to the brain.
What is Cyclooxygenase (COX)? Enzyme involved in the formation of prostaglandins.
When tissue is damaged, chemical mediators are released. Name them. Hydrogen Ions, Histamine, Bradykinin, Prostaglandins, Potassium Ions (**Help! His Brain Processed Pain!)
T or F. Aspirin inhibits both COX1 and COX2? TRUE
What category of drugs fall under nonopioid analgesics? NSAIDs, Acetaminophen
Define Nociceptor. Refers to activation of receptor nerve endings that receive and transmit pain signals to the spinal cord and brain. (Injury to tissues produces nociceptor pain).
Define Neuropathic Pain. Pain caused by direct injury to the nerves and typically is described as burning, shooting, or numb pain. (Responds less successfully to drugs)
What happens when nociceptors are stimulated? The process of pain transmission begins.
A FIbers are characterized as being... covered (myelinated), signal sharp well-defined pain, fast
C Fibers are characterized as being... unmyelinated, conduct dull, poorly localized pain, slow
Two types of sensory neurons that signal pain to spinal cord? A and C Fibers
NSAIDs work at the _________level, whereas Opioids (Narcotics) act within the _____________. Peripheral, CNS
These are used to treat moderate to severe pain levels: Opioids. Moderate efficacy: Codeine and Hydrocodone. High efficacy for severe pain: Morphine and meperidine (Demerol).
Created by: mamcdonald
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