click below
click below
Normal Size Small Size show me how
MIGRAINES
Zolmitriptan
| Question | Answer |
|---|---|
| Expected pharmacological action | Activation of 5HT Receptors which causes vasoconstriction and reduction in neurotransmission. |
| Theraputic Use | Acute migraine headache pain - Selective serotonin drugs are used for the relief of moderate to severe pain and inflammation related to migraine headaches |
| ADRs | ****FLUSHING**** Headache Nausea Dizziness Chest pain Paresthesia into neck dry mouth |
| Contraindications | Allergy to Selective serotonin agonists Ischemic heart disease (cardiovascular), transient ischemic attacks, uncontrolled hypertension, clients taking monoamine oxidase inhibitors (5-HT agonists)(antidepressant) |
| Precautions | Hepatic and Renal Impairment Elderly Dialysis Pregnancy category C Lactation |
| Interactions | Cimetidine - Increased effectiveness of 5-HT agonist Oral Contraceptives - Increased effectiveness of 5-HT agonist |
| Watch out for... | Serotonin syndrome |
| MAX Dose | 10mg in a 24 hr period |
| Client Education | Subcutaneous Injection Administration - only 2 injections in a 24 hour period Impaired skin integrity - become sensitive to light - wear protective clothing and sunscreen when outside - UV rays dangerous, no tanning beds |