Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
NRSG Pharm CH 13
Adrenergic / Antiadrenergic
| Question | Answer |
|---|---|
| agents involved in neurotransmission | catecholamines |
| natural catecholamines / synth catecholamines | N: NE (main, released by most postganglionic nerves), Epi, dopamine S: isoproterenol, dobutamine |
| Adrenergic where? | Adrenergic receptors @ end of postganglionic symp neurons |
| A1 adrenergic receptors, location/response | In all symp target organs except heart. Vasoconstriction, pupil dilation |
| B2 adrenergic receptors, location/response | All symp target organs except heart, INHIBIT smooth muscle |
| NE @ A1 | All symp except heart, vasoconstriction, dilation of pupils |
| NE @ A2 | Presynaptic adrenergic nerve terminals, inhibit release of NE |
| NE @ B1 | Heart and kidneys - Inc HR, force of contraction (CO), renin release (BP inc) |
| NE @ B2 | All symp except heart, inhibit smooth muscle |
| NE @ B3 | Adipose - lipolysis, urinary bladder - relaxation of detrusor muscle |
| 5 mechs by which Rx affect synaptic tx | 1 Affect synthesis of neruotx in terminal 2 prevent storage of neruotx in vesicles in presynaptic 3 influence release 4 prevent normal destruction/reuptake 5 bind @ receptor site on postsynaptic target tissue |
| Prototype: Phenylephrine (Neo-Synephrine) classes, mech | T: nasal decongestant; antihypotensive P: Adrenergic drug (sympathomimetic)) Mech: stimulates symp directly/indirectly - many same responses as anticholinergic |
| Sympathomimetics @ receptors, primary uses: | A1 nasal congestion, hypotension, dilation of pupils -> eye exam A2 hypertension B1 Cardiac arrest, heart failure, shock B2 asthma, premature-labor contractions |
| Side/Adverse sympathomimetics | tachy, hypertension, dysrhythmias, CNS excitation and seizues, dry mouth, N/V, anorexia |
| phenylephrine (Neo-Synephrine) actions/uses | selective alpha-adrenergic agonist, reduces nasal congestion by vasoconstriction in nasal mucosa |
| phenylephrine (neo-Synephrine) side/adverse | uncommon, irritation, rebound congestion if used for prolonged periods |
| Adrenergic considerations: | Vitals, urinary, cardiac breathing patterns responsiveness to light (pupil dilation) Rhinorrhea and epistaxis |
| Adrenergic-blocking agents primary use / other therapeutic applications | Primary: beta blockers for hypertension Other: Angina pectoris, migraines, heart failure |
| Prototype: Prazosin (MiniPress) classes, mech | P: Adrenergic-blocking T: Hypertension drug M: selective A1 adrenergic antagonist - competes with NE @ receptor sites on vascular smooth muscles in arterioles and veins - blocks vasoconstriction of NE @ A1 |
| Prazosin (MiniPress) primary uses: | Hypertension, dysrhythmias, angina, heart failure, benign prostatic hypertrophy, narrow-angle glaucoma |
| Prazosin (MiniPress) adverse: | dizziness, drowsiness, headache, dec energy/strength, palpitations, dry mouth |
| Adrenergic-blocking agents main side/adverse: | Orthostatic hypotension! - rare, can cause LOC 30 min after first dose dizziness, drowsiness, light-headed, reflex tachy |
| adrenergic-blocking considerations | first dose should be low and given at bedtime |
Created by:
kmulla
Popular Pharmacology sets