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Lecture 4
Histone Modification
Question | Answer |
---|---|
What are the lysine modifications? | acetylation, SUMOylation, ubiquitination, biotinylation, methylation |
What are the arginine modifications? | methylation, citrullination |
What are the glutamic acid modifications? | ADP-ribosylation |
What are the serine modifications? | phosphorylation |
What are the threonine modifications? | phosphorylation |
What are the proline modifications? | cis-trans isomerization |
Where does methylation generally occur? | H3 or H4 |
Where does ubiquitylation generally occur? | H2A or H2B |
Where does phosphorylation generally occur? | H3 |
What do HATS do? | promote gene expression; change charge when transcription is on |
What do HDACS do? | deacetylate histones when transcription is off |
What does ubiquitin do? | regulated destruction; single is a signaling modification |
What are the acetylation modifications? | H3K4, H3K9, H3K56, H4K16 |
What are the methylation modifications? | H3K4, H3K9, H3K27 |
What are the ubiquitylation modifications? | H2B C-terminus |
What are the phosphorylation modifications? | H3S10 |