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Pharm Exam 1

TermDefinition
Loading dose higher amount of drug given, plateau reached faster, quickly produces therapeutic response
Maintenance dose Keeps plasma-drug concentration in therapeutic range
Pharmacokinetics Study of drug movement throughout the body
Greatest barrier for many drugs is... Crossing many membranes
4 categories of pharmacokinetic processes Absorption, Distribution, Metabolism, Excretion ADME (Think ADME on snap)
Active transport Usually large, ionized, or water soluble molecules
Passive transport Usually small, nonionized, or lipid soluble molecules
Absorption Movement from site of administration, across body membranes, to circulating fluids
TWhat category of the pharmacokinetic process is the primary factor determining length of time for drug to produce effect? Absorption
Distribution Transport of drugs throughout the body Simplest factor is amount of bloodflow to body tissues
Drug-protein complex Drugs bind reversibly to plasma proteins and never reach the target cell
Blood brain and fetal placenta barriers Amniotic barriers that prevent many chemicals from entering the brain or fetus
Biotransformation Metabolism of medication
Conjugates Side chains that make drugs more water soluble and easily excreted by the kidneys
Hepatic microsomal enzyme system Inactivates drug, accelerates drug excretion
Prodrugs No pharmacologic activity unless first metabolized to active form by body
Created by: sasha.stojk
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