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Lets get drugged
Pharmacology Midterm 2 CNS III
| Question | Answer |
|---|---|
| Clozapine MOA | (atypical antipsychotic) Blocks receptors for dopamine acetylcholine, histamine, norepinepherine &Serotonin. Therapeutic effects due to week dopamine block & strong seratonin block |
| Clozapine IND | Schizophrenia Bipolar (manic phase) |
| Clozapine DI | meds that cause bone marrow suppression |
| Clozapine AE | agranulocytosis (decrease in granulocyte/WBC count leading to an increase in infection) seizures diabetes weight gain sedation orthostatic hypotension |
| Elavil MOA | Tricyclic Antidepressant blocks the neuronal reuptake of seratonin and norepinepherine causing an increase in the effects of neurotransmitters long 1/2 life takes 1-2 mo to have full effect |
| Elavil IND | Depression Bipolar disorder |
| Elavil AE | Sedation orthostatic hypotension anticholinergic effects cardiac toxicity risk of toxicity |
| Elavil Toxicity | death due to the cardiac toxicity in conjunction with anticholinergic effects |
| Elavil DI | MAOI (severe hypertension) direct acting sympathomimetics indirect acting sympathomimetics anticholinergics CNS depressants |
| Prozac MOA | Selective Seratonin Reuptake Inhibitor (SSRI) selective inhibition of seratonin reuptake leading to an increase in concentrationo of seratonin |
| Prozac IND | depression OCD bulimia premenstrual disorder unlabled use: anxiety, alcohol withdraw, ADHD |
| Prozac AE | nausea headache CNS stimulation (nervousness, insomnia, anxiety sexual disfunction weight gain seratonin syndrome withdraw |
| Prozac DI | MAOI warfarin tricyclic antidepressants lithium |
| MAOI MOA | Inhibit the inactivation of norepinepherine and seratonin results in an increased amount of neurotransmitters resulting in intensified effects of Neurotransmitters |
| MAOI IND | reserved for people who don't respond to the safer drugs depression bulimia OCD panic attacks |
| MAOI AE | CNS stimulatin (agitation, anxiety, manic episodes) orthostatic hypotension *hypertensive chrisis from dietary tryamine* |
| MAOI DI | Shouldn't take any meds with out Dr. approval. Tricyclic Antidepressants Selective Seratonin Reuptake Inhibitors antihypertensives demerol indirect acting sympathomimetics |
| Wellbutrin MOA | (atypical antidepressant) unclear MOA blocks the dopamine uptake stimulant actions similar in structure to amphetamines |
| Wellbutrin IND | depression smoking cessaitation |
| Wellbutrin AE | agitation headache weight loss insomnia seizures |
| Wellbutrin DI | MAOI |
| Lithium MOA | (mood stablizer) unknown MOA controls acute manic episodes prevents recurrence of mania or depression short 1/2 life (given in divided doses 3-4x/day |
| Lithium IND | Bipolar disorder |
| Lithium AE | GI disturbances hand tremor polyuria renal toxicity enlarged thyroid gland hypothyroidism |
| Lithium Toxicity | (narrow theraputic range) confusion sedation increase hand tremors blurred vision EKG changes seizures |
| Lithium DI | diuretics non-steroidal anti-inflammatory anticholinergics |
| Benzodiazepine MOA | (valium, Xanax Atavan) quick acting qotientates actions of GABA increase action of GABA leading to decreased anxiety, sedation , muscle relaxation |
| Benzodiazepine IND | anxiety insomnia induce general anesthesia seizure disorders muscle spasms alcohol withdraw |
| Benzodiazepine AE | CNS depression respiratory depression paradoxical reactions (used to decrease anxiety but it ends up increasing anxiety) teratogenic potential for abuse physical dependance |
| Benzodiazepine Toxicity | treat with flumazenil (Romazicon) reverses seditative effects of drug (administered IV) |
| Benzodiazepine DI | CNS Depressants |
| Buspar MOA | (long term intervention) unknown MOA not a CNS depressant -no sedation -no abuse/dependance -doesn't interact with CNS depressants takes a while to reach full effects (2-4 weeks) |
| Buspar AE | dizziness lightheadedness nausea |
| Buspar DI | grapefruit juice (increases drug levels) |
| Ambian MOA | potentates the actions of GABA causes sedation (doesn't help with muscle spasms or anxiety) |
| Ambian IND | insomnia (helps to fall asleep and stay asleep) |
| Ambian AE | daytime drowsiness dizziness |
| Ambian DI | CNS depressants |
| Ritalin MOA | CNS stimulant promotes release of norepinepherine and dopamine theraputic effects: -improved focus -attention -better impulse control -decreased hyperactivity |
| Ritalin IND | narcolepsy ADHD |
| Ritalin AE | insomnia growth suppression |
| Thorzaine MOA | (low potency antipsychotic) blocks receptors for: -dopamine -histamine -acetylcholine -norepinepherine *theraputic effects are a result of dopamine blockage* |
| Thorazine IND | Schizophrenia (specifically positive symptoms) Bipolar disease (manic phase) |
| Thorazine AE | Extrapyramidal symptoms (EPS) -acute distonia (muscle spasms) -parkinsonism -akathisia -tardive diskinisia anticholinergic effects sedation orthostatic hypotension neuroendocrine effects seizures |
| Thorzaine DI | anticholinergics CNS depressants levadopa |
| Haldol AE | (high potency anti-psychotic) increased extrapyramidal symptoms neuroendocrine effects disrythmias *no sedation, anticholinergic effects or hypotension |
Created by:
erinmcgurk
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