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Endocrine 2
Generic Name | Brand Name | Pharmacologic Category | Common Indications | Key Side Effects/Other Notes | US Boxed Warning | US Boxed Warning Cont. | Other Notes |
---|---|---|---|---|---|---|---|
drospirenone and ethinyl estradiol (PO) | Yasmin, Yaz | Contraceptive | Contraception, acne | Key Side Effects: nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache Other Notes: CI in hepatic dysfunction, thromboembolic disorders, breast cancer, and cardiovascular disease | US Boxed Warning: increased risk of cardiovascular events in women >35 years old who smoke | ||
levonorgestrel and ethinyl estradiol (PO) | Lutera, Levora, Seasonique | Contraceptive | Contraception, acne | Key Side Effects: nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache Other Notes: CI in hepatic dysfunction, thromboembolic disorders, breast cancer, and cardiovascular disease | US Boxed Warning: increased risk of cardiovascular events in women >35 years old who smoke | ||
norethindrone and ethinyl estradiol (PO) | Junel, Loestrin, Microgestin | Contraceptive | Contraception, acne | Key Side Effects: nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache Other Notes: CI in hepatic dysfunction, thromboembolic disorders, breast cancer, and cardiovascular disease | US Boxed Warning: increased risk of cardiovascular events in women >35 years old who smoke | ||
norethindrone, ethinyl estradiol, and ferrous fumarate (PO) | Lo Loestrin Fe, Microgestin Fe | Contraceptive | Contraception, acne | Key Side Effects: nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache Other Notes: CI in hepatic dysfunction, thromboembolic disorders, breast cancer, and cardiovascular disease | US Boxed Warning: increased risk of cardiovascular events in women >35 years old who smoke | ||
norgestimate and ethinyl estradiol (PO) | Ortho Tri-Cyclen Lo, Tri-Sprintec, Sprintec | Contraceptive | Contraception, acne | Key Side Effects: nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache Other Notes: CI in hepatic dysfunction, thromboembolic disorders, breast cancer, and cardiovascular disease | US Boxed Warning: increased risk of cardiovascular events in women >35 years old who smoke | ||
norgestrel and ethinyl estradiol (PO) | Crysell-28, Low-Ogestrel | Contraceptive | Contraception, acne | Key Side Effects: nausea, changes in menstrual flow, breast tenderness, thromboembolic disorders, headache Other Notes: CI in hepatic dysfunction, thromboembolic disorders, breast cancer, and cardiovascular disease | US Boxed Warning: increased risk of cardiovascular events in women >35 years old who smoke | ||
estrogens, conjugated (equine) (PO, topical) | Premarin | Estrogen derivative | Vasomotor symptoms associated with menopause, vaginal atrophy associated with menopause | Key Side Effects: irritation at application site (transdermal patch only), abdominal pain, breast tenderness, thromboembolic disorders (myocardial infarction, stroke, VTE) | US Boxed Warning: increased risk of breast cancer; should not be used for dementia prevention; increased risk of endometrial cancer if not used concomitantly with progestin in women with a uterus; disease | US Boxed Warning Cont.: ...... should not be used for prevention of cardiovascular disease | Other Notes: CI in hepatic dysfunction, thromboembolic disorders, cardiovascular disease, breast cancer, and estrogen-dependent tumor |
estradiol (transdermal, PO) | Transdermal: Vivelle Dot, PO: Estrace | Estrogen derivative | Vasomotor symptoms associated with menopause, vaginal atrophy associated with menopause | Key Side Effects: irritation at application site (transdermal patch only), abdominal pain, breast tenderness, thromboembolic disorders (myocardial infarction, stroke, VTE) | US Boxed Warning: increased risk of breast cancer; should not be used for dementia prevention; increased risk of endometrial cancer if not used concomitantly with progestin in women with a uterus; | US Boxed Warning Cont.: ...... should not be used for prevention of cardiovascular disease | Other Notes: CI in hepatic dysfunction, thromboembolic disorders, cardiovascular disease, breast cancer, and estrogen-dependent tumor |
medroxyprogesterone (PO) | Provera | Progestin | Abnormal uterine bleeding, secondary amenorrhea | Key Side Effects: acne, abnormal menstrual bleeding, headache, amenorrhea Other Notes: CI in thromboembolic disorders, cardiovascular disease, estrogen or progesterone-dependent tumors, undiagnosed abnormal genital bleeding, hepatic impairment | US Boxed Warning: increased risk of breast cancer; should not be used for dementia prevention; should not be used for prevention of cardiovascular disease |