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Sulphonamides

QuestionAnswer
Examples 1.Cotrimoxazole= sulfamethoxazole+trimethoprim 2.sulfadiazine 3.silver sulphadiazin 4.sulfasalazine
Mode of action Inhibits nucleic acid synthesis . Sulphonamides structurally simillar to para amino benzoic acid…..
Antibacterial activity Can inhibit gram - and + bacteria. Nocardia, chlamydia trachomatis n some protozoa.
Pharmacokinetics Absorbed rapidly from gut. Excreted by kidneys.
Resistance Occur as a result of mutation causing over production of PABA. Structural change in the folic acid synthesizing enzymes witha a lowered affinity for Sulphonamides.
Interactions Sulphonamides bind to plasma albumin and may displace other drugs such as warfarin, phenytoin, tolbutamide
Contraindications Pregnancy , Infants under 6 weeks, Renal failure, Hepatic failure, Jaundice, Blood disorder, Porphyria
Classification 1.drugs for systemic use 2.drugs for topical use 3.miscellaneous
Drugs for systemic use Cotrimoxazole , Sulphadiazine
Cotrimoxazole Half life 10 hours. 80% excreted by the kidneys.
Uses Prevention and treatment of pneumocystis carinii pneumonia. Prevention and treatment of toxoplasmosis and nocardiasis.
Created by: Angel thili
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