click below
click below
Normal Size Small Size show me how
Anti-Epileptic Drugs
Pharmacology
| AED | |
|---|---|
| Carbamazepine (Class I- Na Channel Blocker) | Tx: best for partial seizures, useful for all other types of seizures except for absence seizures; increases clearance of other drugs; phenobarbital and phenytoin increase metabolism; valproate may inhibit clearance |
| Oxcarbazepine (Class I) | similar to carbazepine but improved safety profile |
| Phenyltoin (Class I) | Tx: generalized tonic-clonic seizures and certain partial seizures, but doesn't completely eliminate the sensory aura and prodromal signs; Side effect: sedation |
| Lamotrigine (Class I) | Tx: tonic-clonic seizures, partial seizures; phentoin, carbamazepine, phenobarbital reduce half-life; valproate increases half-life |
| Felbamate (Class I) | Tx: generalized tonic-clonic and partial seizures; Side effect: aplastic anemia |
| Phenobarbital (Class II- GABA enhancing) | Tx: Generalized tonic-clonic and partial seizures; used in children and pregnant women; inducer of drug metabolism |
| Primidone (Class II) | Tx: Complex partial seizures |
| Tiagabine (Class II) | Tx: partial seizures |
| Vigabatrin (Class II) | Tx: partial seizures |
| Levetiracetam (Class II) | Tx: partial complex seizures |
| Drugs Used in Generalized Seizures (myoclonic seizures, atonic seizures, status epilepticus)- Broad Spectrum Class II | benzodiazepines: diazepam for status epilepticus (low margin of safety), clonazepam for absence seizures |
| Drugs Used in Absence Seizures (Class III- Ca Channel Blockers) | Ethosuximide; By blocking low threshold Ca channels in thalamic pacemaker neurons, prevents large depolarization shifts in membrane potential |
| Drugs Used for Multiple Types of Seizures | valproate, gabapentin, topiramate, zonisamide |