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Anti-Epileptic Drugs

Pharmacology

AED
Carbamazepine (Class I- Na Channel Blocker) Tx: best for partial seizures, useful for all other types of seizures except for absence seizures; increases clearance of other drugs; phenobarbital and phenytoin increase metabolism; valproate may inhibit clearance
Oxcarbazepine (Class I) similar to carbazepine but improved safety profile
Phenyltoin (Class I) Tx: generalized tonic-clonic seizures and certain partial seizures, but doesn't completely eliminate the sensory aura and prodromal signs; Side effect: sedation
Lamotrigine (Class I) Tx: tonic-clonic seizures, partial seizures; phentoin, carbamazepine, phenobarbital reduce half-life; valproate increases half-life
Felbamate (Class I) Tx: generalized tonic-clonic and partial seizures; Side effect: aplastic anemia
Phenobarbital (Class II- GABA enhancing) Tx: Generalized tonic-clonic and partial seizures; used in children and pregnant women; inducer of drug metabolism
Primidone (Class II) Tx: Complex partial seizures
Tiagabine (Class II) Tx: partial seizures
Vigabatrin (Class II) Tx: partial seizures
Levetiracetam (Class II) Tx: partial complex seizures
Drugs Used in Generalized Seizures (myoclonic seizures, atonic seizures, status epilepticus)- Broad Spectrum Class II benzodiazepines: diazepam for status epilepticus (low margin of safety), clonazepam for absence seizures
Drugs Used in Absence Seizures (Class III- Ca Channel Blockers) Ethosuximide; By blocking low threshold Ca channels in thalamic pacemaker neurons, prevents large depolarization shifts in membrane potential
Drugs Used for Multiple Types of Seizures valproate, gabapentin, topiramate, zonisamide
Created by: DrCutiepie
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