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Adrenocort. Steroids

Pharmacology

ACTH & Adrenocortical Steroids
Natural Glucocorticoids cortisol, cortisone
Synthetic Glucocorticoids Prednisone, Dexamethasone, Betamethasone
Metyrapone Tx: adrenal hyperactivity; inhibits 11B-hydroxylation
CRF adrenal hyperactivity diagnostic tool; patients with pituitary adenoma show enhanced responsiveness to CRF, whilethose with an adrenal tumor or ectopic ACTH production show diminished response
Mitotane Tx: Adrenal hyperactivity; selectively destroys adrenocortical cells, both normal and neoplastic
Aminoglutethimide Tx: Adrenal hyperactivity; inhibits conversion of cholesterol to 20-alpha-hydroxycholesterol
Naturally-occurring Mineralcorticoids Aldosterone, DOCA, Corticosterone
Synthetic Mineralocorticoids Fludrocortisone
Spironolactone Aldosterone antagonist
Desmopressin, Vasopressin potent V2 agonists
Tolvaptan Tx: congestive heart failure, polycystic kidney disease; kidney V2 antagonist
Relcovaptan Tx: pre-term labor; smooth muscle V1a antagonist
Created by: DrCutiepie
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