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RADIOBIOLODY
BIOLOGICAL EFFECTS OF IONIZING RADIATION
Question | Answer |
---|---|
defined as the branch of science concerned with the methods of interaction and the effects of ionizing radiation on living systems. | RADIOBIOLOGY |
Ionizing radiation causes cellular structures to become ionized or excited. These ionizations can: | -Produce free radicals -Break chemical bonds -Produce new chemical bonds and cross linkage between macromolecules -Damage molecules that regulate vital cell processes |
And advisory committee that publishes reports on the effects of ionizing radiation on biological systems | BIER |
Dose required to kill a certain fraction of a given group of irradiated objects within a given time fram | LETHAL DOSE |
-Easily damaged -Easily replaced -Respond to radiation quickly | RADIOSENSITIVE |
-Hard to damage -Hard to replace -Show no immediate response - | RADIORESISTANT |
LAW OF BERGONIE AND TRIBONDEAU | -The more mature a cell is the more resistant it is -The younger the tissues and organs the more sensitive -radiosensitivity is high when metabolic activity is high -As proliferation and growth rate increase so does the radiosensitivity |
LAW OF BERGONIE AND TRIBONDEAU | -Radiosensitivity of a cell is directly proportional to proliferation but, inversely proportional to cell differentiation |
FACTORS OF BIOLOGICAL DAMAGE | -The quantity of radiation received in a given time period -The ability(quality) of the radiation to cause ionization i.e. RBE,LET,Q.F. -The amount of the body are exposed -The specific part(s) of the body that are exposed |