Busy. Please wait.
or

show password
Forgot Password?

Don't have an account?  Sign up 
or

Username is available taken
show password

why


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.

Remove ads
Don't know
Know
remaining cards
Save
0:01
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
Retries:
restart all cards




share
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Anxiety Pharma

Behavioral Medicine Pharmacology

QuestionAnswer
Anti-anxiety med: adequate trial = 6-8 weeks
Classes of anti-anxiety drugs Benzodiazepines; SSRIs; SNRIs; Buspirone; other (hydroxyzine, imipramine, and propranolol)
Which drugs are firstline for anxiety? Benzodiazepines; SSRIs; SNRIs
Tx of choice for acute anxiety relief Benzodiazepines
Anxiety tx of choice for noncompliance / avoidance of withdrawal sx Diazepam
Advantage of buspirone lack of sedation AE; good if pt h/o substance abuse
Advantage of beta blockers in anxiety tx good for pt w/ hx of CV sx; adjunct for refractory
MOA: Benzodiazepines Potentates inhibitory effect of GABA
MOA: SSRIs Selectively inhibit the reuptake of 5-HT by blocking the 5-HT transporter
MOA: SNRIs Block the reuptake of 5-HT and NE (and DA)
MOA: Buspirone SSRI
MOA: Hydroxyzine Potent antihistaminergic, anticholinergic, and antispasmodic effects
MOA: Imipramine (TCA) Blocks reuptake of 5-HT and NE
MOA: propranolol beta-blocker
Bz side effects CNS depression / sedation; anterograde amnesia; dependence / abuse
Shorter acting benzodiazepines Alprazolam; Lorazepam; Oxazepam
Longer acting benzodiazepines Chlordiazepoxide; clonazepam; Diazepam
Benzodiazepines: increased toxicity / mortality if: taken with other CNS depressants
Benzodiazepine OD mild sx drowsy, confusion, somnolence, impaired coordination, diminished reflexes, lethargy
Benzodiazepine OD serious sx ataxia, hypotonia, hypotension, hypnosis, coma, death
Benzodiazepine OD: Tx: gastric lavage, supportive measures, flumazenil
Benzodiazepine Withdrawal Sx anxiety, restlessness, insomnia, agitation, muscle tension, irritability
Bz withdrawal sx more likely in: users of high doses for long periods of time
Tx: Bz withdrawal Taper over several weeks when discontinuing
Antidepressants for anxiety dz: SSRIs; Venlafaxine; Mirtazipine; TCA; MAOI
SSRI dosing for anxiety delayed tx response; initiate w/smaller dose than AD dose
Anxiety: MAOI reserved for: refractory cases
FDA approved for panic disorder paroxetine, fluoxetine, sertraline, venlafaxine XR, alprazolam, clonazepam
Tx for OCD CBT firstline for mild; CBT and SSRI for severe (clomipramine if 2-3 failed SSRIs); tx mania, depression, or psychosis first
Created by: Abarnard