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week 3 sherpath

Pharmacodynamics

QuestionAnswer
Which statement is accurate regarding the graph? Meperidine has greater efficacy than pentazocine.
If the body eliminates a drug more slowly than the drug enters the body, which conditions can occur? Toxic concentration Increased side effects
When monitoring for therapeutic response in a patient prescribed a new drug, it is important for the nurse to understand it takes about _______________ half-lives for a drug to reach steady state. 4
Based on the drug-receptor interactions shown, which drug will have the best effect on a patient treated for hypertension? B
Match the receptor family to its description. Binding site is on cell surface. Cell membrane channel opens, and ions flow into and out of the cells. Takes three steps to activate this receptor response. Activation of receptors through this family regu Cell membrane-embedded enzymes Ligand-gated ion channels G protein-coupled receptor systems Transcription factors
Which type of drug can mimic or block the actions of receptors? Partial agonists
Which term describes the most likely cause of orthostatic hypotension that occurs in a patient who is taking six different drugs? Drug-drug interaction
Which drug may cause toxicity when taken with grapefruit juice? Cyclosporine
Patients may experience reduced effectiveness of which drugs when taken with St. John’s wort? Digoxin Warfarin Oral contraceptives
Which patients are more vulnerable to adverse effects? Pediatric patients Older adult patients Patients with chronic illness
Match the type of adverse effect with its description. Results from decreased drug clearance Usually requires prior exposure Genetically determined abnormal response to a drug Dose-related adverse effect Allergic adverse effect Idiosyncratic effect
Nurses understand patients taking which narrow therapeutic index (TI) drugs require close monitoring of blood levels to adjust dosing? Digoxin Lithium Warfarin Phenytoin
A patient is prescribed an increased dose of a drug to improve control of their blood pressure. A week later, there is no change in the patient’s blood pressure (BP). Which phase of the dose-response curve might this reflect? Phase 3
Which time frame is appropriate for obtaining a peak level from a patient receiving intravenous vancomycin? 30 to 60 minutes
When providing care for a person who has stopped taking a drug with a half-life of 4 hours, how long will it take for 94% of the drug to leave the body? 16 hours
Which of the four receptor families regulates protein synthesis? Transcription factors
Which drug best meets the criteria for a selective drug? A drug that blocks M1 and M2 receptors in the bladder
Which types of drugs work through physical or chemical reactions rather than through receptor binding? Antacids Hormones Saline laxatives Chelating agents
Which common symptoms may indicate a drug-drug interaction in a patient taking multiple drugs? Nausea Heartburn Headache Lightheadedness
Match the effect of the drug interaction to its example. Administering a diuretic and beta blocker for hypertension Using two cytotoxic drugs to treat cancer at lower doses than if given alone Adding a bacterial enzyme inhibitor to an antibiotic Givin Additive Synergistic Potentiation Antagonistic
Which drug(s) classes interact adversely with cheeses? Tetracyclines Monoamine oxidase (MAO) inhibitors Fluoroquinolones
After administering lorazepam to an older adult patient with restlessness and crying, the patient becomes hostile and aggressive and has angry outbursts and psychomotor agitation. Which type of adverse drug effect is the patient experiencing Paradoxical reaction
Nurses understand that to provide for patient safety with respect to drug administration, they should take which actions? Teach patients about the side effects of drugs they take Teach the patient in an environment conducive to learning Provide education in a manner appropriate to the patient’s cognitive abilities
Created by: Brandi Sizemore
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