Save
Busy. Please wait.
Log in with Clever
or
show password
Forgot Password?
Don't have an account?  Sign up 
Sign up using Clever
or
Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account. Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
edit
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Sherpath

Week 3 Sherpath Pharmacokinetics

QuestionAnswer
Match the factor affecting absorption with its characteristics. Explains why oral drugs are formulated to be absorbed from small intestine Surface area Drug that easily crosses membranes that separate it from the blood Lipid soluble Process where dru surface area lipid soluble pH partitioning rate of dissolution
Which route of administration provides rapid onset of delivery to enhance safety and efficacy? Intravenous
Which route of administration provides rapid onset of delivery to enhance safety and efficacy? Rectal drugs are rapidly absorbed. Absorption of rectal drugs is unpredictable. Defecation can interrupt absorption of rectal drugs.
Which factors affect drug distribution? Blood flow to tissues Ability of drug to exit blood vessels Ability of drug to enter cells
Which statements about protein binding are accurate? The portion of drug that remains unbound is active. Only unbound drugs can exert pharmacologic responses. The portion of drug that is bound cannot exit blood vessels.
Which drugs are able to cross the blood-brain barrier (BBB)? Highly lipid-soluble drugs Low molecular weight drugs Drugs bound to transport proteins
The liver metabolizes drugs into which component for renal excretion? Water-soluble substance
Only _______ of the 12 closely related cytochrome P450 enzyme families metabolize drugs. Use numbers only. 3
Which factors decrease drug metabolism? Malnutrition Kidney disease Cardiovascular disease
Match each step in renal drug excretion to its definition. Moves drugs from blood to urine Lipid-soluble drugs move back into the blood “Pumps” for organic acids and bases move drugs from blood to urine Glomerular Filtration Passive Tubular Reabsorption Active Tubular SEcretion
Which organ accounts for most drug excretion, thereby limiting the duration of action of many drugs? kidneys
Drugs are excreted by which routes? Feces Lungs Breast milk
Which route of drug administration is most likely to be reversible? oral
Which route of drug administration delivers drugs directly to the tissue where they exert their actions? Inhalational
Which factors may affect drug absorption? Surface area Lipid solubility Rate of dissolution
Which conditions decrease blood flow to tissues, thereby reducing the effectiveness of drug therapy? Abscess Solid tumor
The nurse knows that warfarin is 99% protein bound, whereas bupropion is 84% protein bound. If both of these drugs are administered concurrently, which events could occur? Warfarin could displace bupropion from its binding site. Bupropion could accumulate to toxic levels.
To safely administer drugs, nurses must understand that only certain drugs can cross the blood-brain barrier (BBB), including those that are highly lipid soluble and of low molecular weight. Which drug can cross the BBB? Diazepam
Match the possible consequence of drug metabolism to its example. Conversion of procaine into para-aminobenzoic acid (PABA) Conversion of codeine into morphine Conversion of acetaminophen into metabolite Conversion of lipid-soluble drugs into water-so Drug inactivation Increased therapeutic action Increased toxicity Increased renal secretion
Which routes of administration can be used to avoid the first-pass effect? Topical Intranasal Intravenous Inhalational
Which factors alter drug metabolism in older adults? Decreased liver mass Decreased hepatic blood flow
Kidney stones and urinary obstruction alter which pharmacokinetic principle? excretion
Certain drugs must undergo which process before enterohepatic recirculation can occur? Glucuronidation
Drugs with which property are excreted in breast milk? Lipid soluble
Created by: Brandi Sizemore
Popular Pharmacology sets

 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards