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Oxygen Transport I

QuestionAnswer
Amount of O2 dissolved in each ml of plasma For every 760 mmHg pressure, .023 ml of O2 dissolves in each ml of plasma
Calculation of O2 dissolved in blood PO2 x .003
How many Hb molecules are in each RBC? 280 million
How many heme groups and amino acid chains are in normal Hb? 4 heme groups, 4 amino acid chains
When can Hb be said to be 100% saturated with O2? When 4 O2 molecules are bound to 1 Hb molecule
When hb is bound with 3 O2 molecules it is ___% saturated. 75%
Hb bound with O2 oxyhemoglobin
Hb not bound with O2 deoxyhemoglobin
Amt. of Hb bound to O2 is directly related to PP of O2
Normal Hb for male 14-16g/100 ml of blood (g%)
Normal Hb for female 12-15g%
Each g% is capable of carrying about ___ ml of O2 1.34
At normal PaO2 of 100, what is the saturation and why? Sat is 97% because of normal physiologic shunting
Oxyhemoglobin dissociation curve sigmoid curve that results at O2 tensions between 0-150 mmHg, shows the relationship between PO2 and Hb at the lungs and at the tissues
Sigmoidal curve indicates Hb's affinity for O2 provides 97% saturation at the normal arterial tension of 100 mmHg, and a 75% saturation at the normal mixed venous tension of 40 mmHg
Right shift P50 value > 27, indicates decreased affinity
Left Shift P50 value < 27, indicates increased affinity
P50 Normal Hb is 50% saturated with the O2 at a PaO2 of 27 mmHg
PO2 60-100 Still 90% saturated
What promotes the pickup and delivery of O2? PCO2, pH, and temperature
Clinical signs of hypoxia Tachycardia, hyperventilation, restlessness, hypertension (early), hypotension (late), confusion and disorientation, possible cyanosis, lactic acidosis, polycythemia
Hypoxemic hypoxia Decreased alveolar ventilation, decreased inspired oxygen tension, ventilation to perfusion mismatch, diffusion defect
Anemic hypoxia Carbon monoxide poisoning, abnormal Hb--methemoglobinemia, low Hb, sickle cell
Circulatory hypoxia Bradycardia, hypotension, low cardiac output, cardiac arrest
Histotoxic hypoxia Inability to accept and use O2 as seen in cyanide poisoning
The only hypoxia where a patient will always also be hypoxemic is: Hypoxemic hypoxia--PaO2 can be normal in other types
Cyanosis Generally more than 5gm% of reduced Hb results in cyanosis
Created by: 1421350383