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lipid pharmacology
lipid lowering agents
| Question | Answer |
|---|---|
| bile acid sequestrants ( colestipol, cholestyramine) | bind bile acids in intestinal lumen and prevent their reabsorption, may relieve pruitis in patients with cholestasis and bile salt accumulation |
| bile acids sequestrants ( colestipol, cholestyramine) | adverse effects--> constipation bloating heart burn diarrhea vitamin K/folic acid deficiences |
| bile acid sequestrants ( colestipol, cholestyramine) | interactions--> digitalis, thiazides, warfarin, tetracycline, thyroxine |
| gemfibrozil | increases peripheral catabolism of VLDL and chylomicrons by increasing lipoprotein lipase |
| gemfibrozil | reduces hepatic synthesis of cholesterol |
| gemfibrozil | adverse effects--> rashes, GI symptoms, myopathy, arrythmias, hypokalemia |
| niacin | reduces plasma VLDL by inhibiting synthesis, markedly decreases plasma triglycerides, HDL levels increase |
| niacin | adverse effects--> flushing and ithching or burning feeling in the skin; increase transaminase activity;hyperglycemia; GI disturbances; peptic ulcer; reanl effects; and macular edema |
| statins | competitevly inhibit HMG-COa reductase in cholesterol synthesis; results in increased hepatic uptake of plasma cholesterol by increasing number of LDL receptors |
| statins | adverse effects--> myositis, hepatotoxicity, and elevations in aminotransferases |
Created by:
swohlers
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